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|Year : 2000 | Volume
| Issue : 2 | Page : 108--113
Probucol protects against gentamicin-induced nephrotoxicity in rats
Kumar K Vijay1, MUR Naidu2, A Anwar3, Shifow4, KS Ratnakar5
Objective: To investigate the effect of probucol on gentamicin-induced nephrotoxicity in rats.
Methods: Male Wistar rats were divided into 4 groups; normal saline, gentamicin 80 mg/kg, i.p., intraperitoneally for 8 days, probucol 10 mg/kg, p.o., for 11 days, probucol 3 days and concurrently with gentamicin for 8 days. Blood urea, serum creatinine, plasma malondialdehyde (MDA), creatinine clearance, urinary sodium, potassium and microscopic examination of kidney were performed after the treatment.
Results: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in blood urea and serum creatinine. Blood urea and serum creatinine were increased by 963% and 462% respectively with gentamicin compared to saline-treated animals. Co-administration of probucol with gentamicin decreased the rise in blood urea and serum creatinine. Creatinine clearance (Ccr) was significantly decreased by 89% with gentamicin compared to control. Treatment with probucol improved Ccr by 24% compared to gentamicin treated group. There was a 177% rise in lipid peroxidation products (MDA) with gentamicin than control, which was significantly reduced by 44% with probucol. Study of renal morphology by light microscope showed epithelial loss with intense granular degeneration involving >50% renal cortex in gentamicin treated rats, whereas in probucol plus gentamicin treated rat revealed insignificant changes in tubular epithelium.
Conclusion: Our data suggest that supplementation of probucol may be useful in reducing gentamicin nephrotoxicity in rats.
Kumar K Vijay
|How to cite this article:|
Vijay KK, Naidu M, Anwar A, Shifow, Ratnakar K S. Probucol protects against gentamicin-induced nephrotoxicity in rats.Indian J Pharmacol 2000;32:108-113
|How to cite this URL:|
Vijay KK, Naidu M, Anwar A, Shifow, Ratnakar K S. Probucol protects against gentamicin-induced nephrotoxicity in rats. Indian J Pharmacol [serial online] 2000 [cited 2021 Oct 24 ];32:108-113
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=2;spage=108;epage=113;aulast=Vijay;type=0