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|Year : 1998 | Volume
| Issue : 5 | Page : 334--338
Effect of serotonergic agents on amphetamine induced stereotypy
CS Kandi1, BR Metkar2, VS Kasture3, SB Kasture4
0bjective:To study the effect of serotonergic agents on the amphetamine induced sniffing, biting, grooming and repetitive head movements.
Methods:Effect of pretreatment with parachlorophenylalanine, I-tryptophan,fluoxetine, (+)fenfluramine, buspirone, cyproheptadine and ianserin on amphetamine induced sniffing and biting (in rats) and grooming and repetitive head movements (in mice) were observed.
Results: Latency to sniffing and biting was decreased by parachlorophenylalanine and increased by buspirone, I-tryptophan, fenfluramine and mianserin. Latency to grooming was increased by I-tryptophan, fenfluramine and fluoxetine and decreased by cyproheptadine, parachlorophenylalanine, mianserin and buspirone.The latency to repetitive head movements was reduced by I tryptophan, fenfluramine and increased by cyproheptadine, parachlorophenylalanine, mianserin and buspirone.
Conclusion: Serotonergic agents modify amphetamine induced stereotypy. The serotonergic agents produce differential effects on different components of amphetamine stereotypy
C S Kandi
|How to cite this article:|
Kandi C S, Metkar B R, Kasture V S, Kasture S B. Effect of serotonergic agents on amphetamine induced stereotypy.Indian J Pharmacol 1998;30:334-338
|How to cite this URL:|
Kandi C S, Metkar B R, Kasture V S, Kasture S B. Effect of serotonergic agents on amphetamine induced stereotypy. Indian J Pharmacol [serial online] 1998 [cited 2022 Oct 1 ];30:334-338
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=5;spage=334;epage=338;aulast=Kandi;type=0