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Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 220--223

Opiate excretion profile among heroin dependent subjects by TLC densitometry

Jain Raka1, Ray Rajat2, BM Tripathi3, Singh Chandni4 
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Jain Raka


Urinary excretion profile of total morphine (free and conjugated) was examined in human volunteers after acute administration. Six heroin dependent subjects received single intramuscular injection of 30 mg morphine following their detoxification. Serial urine specimens were collected before and al libitum for 48 h following administration of the drug. Morphine was assayed by thin layer chromatography (TLC) and densitometric methods. Peak concentration was observed within 5 h and the drug was detectable up to 12 h. Total morphine excreted by 12 h was about 61% of total dose. Detection limit of total morphine in our laboratory by the above techniques was 0.5 (glml. The TLC and densitometric techniques are simple, rapid and may be used for detecting morphine in heroin dependent subjects.


How to cite this article:
Raka J, Rajat R, Tripathi B M, Chandni S. Opiate excretion profile among heroin dependent subjects by TLC densitometry.Indian J Pharmacol 1996;28:220-223


How to cite this URL:
Raka J, Rajat R, Tripathi B M, Chandni S. Opiate excretion profile among heroin dependent subjects by TLC densitometry. Indian J Pharmacol [serial online] 1996 [cited 2021 Feb 25 ];28:220-223
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=4;spage=220;epage=223;aulast=Raka;type=0