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Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 185--187

Bioavailability of diclofenac sodium: comparison of rectal suppositories with oral suspension in rabbits

Ramkrishna Sistla1, V Srinivas2, Prakash3, V Diwan4 
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Correspondence Address:
Ramkrishna Sistla


Compressed rectal suppositories which are suitable and stable in tropical climates were formulated using diclofenac sodium, a potent NSAID, in polyethylene glycol 4000 base. These suppositories were evaluated for pharmacokinetic performance in rabbits at the dose of 10 mg/kg and the results were compared with those obtained after oral administration. A computer programme using model independent formulae was used to calculate different pharmacokinetic parameters. There was no difference in pharmacokinetic parameters such as Cmax, AUC0-(, t1/2 and the mean residence time (MRT) between oral and rectal formulations. But tmax was faster in case of oral administration (0.58 0.08 h vs 1.08 0.15 h, P < 0.05) indicating quicker drug absorption from oral suspension. Relative rectal bioavailability was 98.35 3.58% which indicates comparable pharmacokinetic performance of rectal suppositories of diclofenac sodium in rabbits.


How to cite this article:
Sistla R, Srinivas V, Prakash, Diwan V. Bioavailability of diclofenac sodium: comparison of rectal suppositories with oral suspension in rabbits.Indian J Pharmacol 1996;28:185-187


How to cite this URL:
Sistla R, Srinivas V, Prakash, Diwan V. Bioavailability of diclofenac sodium: comparison of rectal suppositories with oral suspension in rabbits. Indian J Pharmacol [serial online] 1996 [cited 2020 Oct 28 ];28:185-187
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=3;spage=185;epage=187;aulast=Sistla;type=0