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Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 222--226

Disposition kinetics of sulphamethoxypyridazine during endotoxin induced fever and its modification by sodium salicylate in goats

S Juliet1, A Barman2, S Majumder3, TK Mandal4, AK Chakraborty5 
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Correspondence Address:
S Juliet


Disposition kinetics of sulphamethoxypyridazine (25 mg/kg, i.v.) in absence and in presence of sodium salicylate (50 mg/kg, i.v.) in both afebrile and endotoxininduced febrile conditions were studied in female black Bengal goats. The disposition kinetics of sul phamethoxypyridazine alone and in presence of sodium salicylate were described by a two compartment and one compartment model respectively. Sulphamethoxypyridazine persisted in afebrile and febrile goats till 36 and 24 h post administration, while in presence of sodium salicylate it persisted till 30 and 24 h in afebrile and febrile goats. Sodium salicylate decreased the plasma protein binding activity of sulphamethoxypyridazine. Besides, sodium salicylate decreased the t1/2(() , Vd(area) (P < 0.01); and increased the AUC value of sulphamethoxy-pyridazine.


How to cite this article:
Juliet S, Barman A, Majumder S, Mandal T K, Chakraborty A K. Disposition kinetics of sulphamethoxypyridazine during endotoxin induced fever and its modification by sodium salicylate in goats.Indian J Pharmacol 1995;27:222-226


How to cite this URL:
Juliet S, Barman A, Majumder S, Mandal T K, Chakraborty A K. Disposition kinetics of sulphamethoxypyridazine during endotoxin induced fever and its modification by sodium salicylate in goats. Indian J Pharmacol [serial online] 1995 [cited 2021 Aug 4 ];27:222-226
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1995;volume=27;issue=4;spage=222;epage=226;aulast=Juliet;type=0