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Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 301--303

A non-invasive method for screening hepatoprotective drugs against carbon tetrachloride induced hepatotoxicity

D Visweswaram1, Rao P Rajeswara2, S Satyanarayana3 
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Correspondence Address:
D Visweswaram


Carbon tetrachloride (CCl4 ) a pharmacological tool to produce liver damage reduced the urinary excretion of ascorbic acid in rats. Silymarin and extract of Pamarus (shown to be hepatoprotective substances) prevented the CCl4 induced reduction of ascorbic acid excretion in urine. The results indicate that the measurement of ascorbic acid excretion can be used as a non-invasive test for screening protective substances against CCl4 induced hepatotoxicity in rats.


How to cite this article:
Visweswaram D, Rajeswara RP, Satyanarayana S. A non-invasive method for screening hepatoprotective drugs against carbon tetrachloride induced hepatotoxicity.Indian J Pharmacol 1994;26:301-303


How to cite this URL:
Visweswaram D, Rajeswara RP, Satyanarayana S. A non-invasive method for screening hepatoprotective drugs against carbon tetrachloride induced hepatotoxicity. Indian J Pharmacol [serial online] 1994 [cited 2021 Sep 21 ];26:301-303
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=4;spage=301;epage=303;aulast=Visweswaram;type=0