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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 227--228

Anticonvulsant activity of pyrimidine thiols

AK Gupta1, Sanjay2, HP Kayath3, Singh Ajit4, Sharma Geeta5, KC Mishra6 
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Correspondence Address:
A K Gupta


A series of nitrophenyl 4,4,6 trimethyl, 1 H, 4H pyrimidine 2 thiols (NPTP) were synthesised and tested for their anticonvulsant activity in mice against maximal electro shock and metrazol (MET) induced convulsions. Test compounds were given in graded doses (20,40,60,80 mg/Kg i.p.) and compared with phenobarbitone as a standard control. The protection produced by the test compounds was dose dependent. Phenobarbitone, produced 100% protection in the dose of 50 mg/Kg, whereas test compounds exhibited the same effect with 80 mg/Kg except 2 NPTP against MET induced convulsions.


How to cite this article:
Gupta A K, Sanjay, Kayath H P, Ajit S, Geeta S, Mishra K C. Anticonvulsant activity of pyrimidine thiols.Indian J Pharmacol 1994;26:227-228


How to cite this URL:
Gupta A K, Sanjay, Kayath H P, Ajit S, Geeta S, Mishra K C. Anticonvulsant activity of pyrimidine thiols. Indian J Pharmacol [serial online] 1994 [cited 2020 Nov 29 ];26:227-228
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=3;spage=227;epage=228;aulast=Gupta;type=0