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Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 159--161

Adenosine enhances analgesic effect of tricyclic antidepressants

SS Pareek1, CT Chopde2, Desai PA Thakur3 
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2 
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Correspondence Address:
S S Pareek


lntraperitoneal administration of adenosine (10 mg/kg) enhanced the analgesic effect of tricyclic antidepressant (TCA) imipramine or amitriptyline in the tail flick test. Theophylline (50 mg/kg) or caffeine (50 mg/kg), purinoceptor antagonists, attenuated the analgesic response not only of TCA alone but also of adenosine and TCA combination. These results indicate that TCA induced analgesia may be mediated through adenosinergic system and thus provide new evidence for their interaction.


How to cite this article:
Pareek S S, Chopde C T, Thakur DP. Adenosine enhances analgesic effect of tricyclic antidepressants.Indian J Pharmacol 1994;26:159-161


How to cite this URL:
Pareek S S, Chopde C T, Thakur DP. Adenosine enhances analgesic effect of tricyclic antidepressants. Indian J Pharmacol [serial online] 1994 [cited 2022 Aug 15 ];26:159-161
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=2;spage=159;epage=161;aulast=Pareek;type=0