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Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 156--158

Effect of pyrogen induced fever on the biokinetics of cefazolin in goats

BK Roy1, KP Yadava2, NC Banerjee3 
1 
2 
3 

Correspondence Address:
B K Roy


Biokinetics of cefazolin (CFZ) after single dose i.m. at the dose of 30 mg/kg was studied in afebrile and febrile goats. The mean cpmax of CFZ was higher (33.00 ( 2.14 (g ml-1) in afebrile as compared to that in febrile goats (19.59 (1.93 (gml-1). However, the tcpmer remained the same (4.0 h) in both the groups. The t1/2( mean value was significantly (P < 0.05) longer in the febrile goats (1.42 ( 0.14 h) as compared to that in the normal (1 .OO ( 0.04 h). The average AUC was significantly (P < 0.01) larger in normal goats (62.88 ( 4.30 (g ml-1) than that in the febrile goats (47.70 ( 2.61 (g ml-1). The dosage regimen of CFZ calculated on the basis of relevant biokinetic parameter under febrile situation has been suggested.


How to cite this article:
Roy B K, Yadava K P, Banerjee N C. Effect of pyrogen induced fever on the biokinetics of cefazolin in goats.Indian J Pharmacol 1994;26:156-158


How to cite this URL:
Roy B K, Yadava K P, Banerjee N C. Effect of pyrogen induced fever on the biokinetics of cefazolin in goats. Indian J Pharmacol [serial online] 1994 [cited 2022 Jun 30 ];26:156-158
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=2;spage=156;epage=158;aulast=Roy;type=0