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Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 224--227

Evidence for alpha-2 adrenoceptor agonist activity of hydralazine

MC Satia1, RK Goyal2 
1 
2 

Correspondence Address:
M C Satia


Hydralazine (5.08 x 10-5 M to 1.5 x 10-3M ) produced a dose-dependent inhibition of field stimulation evoked responses on rat anococcygeus muscle and vas-deferens. This was antagonized competitively by yohimbine. On estrogen primed rat uterus, hydralazine produced a dose-dependent relaxation which was competitively blocked by yohimbine and propranolol but not by cimetidine. The responses to hydralazine were significantly inhibited by reserpine pre-treatment (5mg/kg, i.p., 24 h. before). Our data suggests alpha2-adrenoceptor agonist activity of hydralazine.


How to cite this article:
Satia M C, Goyal R K. Evidence for alpha-2 adrenoceptor agonist activity of hydralazine.Indian J Pharmacol 1993;25:224-227


How to cite this URL:
Satia M C, Goyal R K. Evidence for alpha-2 adrenoceptor agonist activity of hydralazine. Indian J Pharmacol [serial online] 1993 [cited 2021 Sep 19 ];25:224-227
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=4;spage=224;epage=227;aulast=Satia;type=0