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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 149--153

3-Cyano-4-methyl-5vinyl pyridine: a potent synthetic hepatoprotective agent

PKS Visen1, Saraswat Binduja2, GK Patnaik3, RC Srimal4, RP Tripathi5, DS Bhakuni6 
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Correspondence Address:
PKS Visen


Compound 3-cyano-4-methyl-5-vinyl pyridine (compound 89/62) produced a dose dependent (3-12 mg/kg, p.o.) choleretic activity in rats and significant anticholestatic activity (38-l00%) against paracetamol induced cholestasis. It also increased the viability of hepatocytes as assessed by trypan blue exclusion and oxygen uptake tests, Paracetamol induced biochemical changes in serum and isolated hepatocytes were normalised by the pretreatment with this compound.


How to cite this article:
Visen P, Binduja S, Patnaik G K, Srimal R C, Tripathi R P, Bhakuni D S. 3-Cyano-4-methyl-5vinyl pyridine: a potent synthetic hepatoprotective agent.Indian J Pharmacol 1993;25:149-153


How to cite this URL:
Visen P, Binduja S, Patnaik G K, Srimal R C, Tripathi R P, Bhakuni D S. 3-Cyano-4-methyl-5vinyl pyridine: a potent synthetic hepatoprotective agent. Indian J Pharmacol [serial online] 1993 [cited 2021 Jun 15 ];25:149-153
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=3;spage=149;epage=153;aulast=Visen;type=0