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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 146--148

Drug interaction of tolbutamide with ketoconazole in diabetic rabbits

YSR Krishnaiah1, S Satyanarayana2, D Visweswaram3 
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Correspondence Address:
YSR Krishnaiah


A study was carried out to find out the therapeutic implications of the tolbutamide - ketoconazole interaction in diabetic rabbits. Ketoconazole treatment (20 mgkg, oral once daily for one week) significantly increased and prolonged the antidiabetic effect of tolbutamide (40 mg/kg, oral) in diabetic rabbits. The AUC0-( and the terminal half-life of tolbutamide were increased significantly by ketoconazole indicating the decrease in its hepatic metabolism.


How to cite this article:
Krishnaiah Y, Satyanarayana S, Visweswaram D. Drug interaction of tolbutamide with ketoconazole in diabetic rabbits.Indian J Pharmacol 1993;25:146-148


How to cite this URL:
Krishnaiah Y, Satyanarayana S, Visweswaram D. Drug interaction of tolbutamide with ketoconazole in diabetic rabbits. Indian J Pharmacol [serial online] 1993 [cited 2021 Jun 20 ];25:146-148
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=3;spage=146;epage=148;aulast=Krishnaiah;type=0