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Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 140--145

Effect of lead on 5-hydroxytryptamine induced contractions in rat ileum and its modification by magnesium and reserpine

DN Gandhi1, Bhatt H Venkatakrishna2 
1 
2 

Correspondence Address:
D N Gandhi


Effects of lead (Pb) on 5-hydroxytryptamine (5-HT) induced contractions of isolated rat ileum and its modification by magnesium (Mg++) and reserpine were studied. Preparations incubated in Mg++ free or excess Mg++media showed supersensitivity and subsensitivity to 5-HT respectively. Reserpinization failed to induce supersensitivity to 5-HTin any Mg++ concentration of the medium, but in Mg++ free with ethylene diamine tetra acetic acid (EDTA) showed increased sensitivity to 5-HT. The inhibition observed with Pb in Mg++ with EDTA was comparatively less in both non-reserpinized and reserpinized preparations. Pb reduced the sensitivity and decreased the maximal responses to 5-HT in all Mg++ concentration of the medium tested.


How to cite this article:
Gandhi D N, Venkatakrishna BH. Effect of lead on 5-hydroxytryptamine induced contractions in rat ileum and its modification by magnesium and reserpine.Indian J Pharmacol 1993;25:140-145


How to cite this URL:
Gandhi D N, Venkatakrishna BH. Effect of lead on 5-hydroxytryptamine induced contractions in rat ileum and its modification by magnesium and reserpine. Indian J Pharmacol [serial online] 1993 [cited 2021 Jun 20 ];25:140-145
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=3;spage=140;epage=145;aulast=Gandhi;type=0