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Year : 1992  |  Volume : 24  |  Issue : 1  |  Page : 36--37

Disposition kinetics and dosage regimen of gentamicin in rabbits following intramuscular administration:

RP Uppal1, SP Verma2, SK Garg3, RK Roy4 
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2 
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Correspondence Address:
R P Uppal


Pharmacokinetics and dosage regimen of gentamicin were investigated in rabbits following a single intramuscular administration of 4mg/kg. The absorption and elimination half lives and apparent volume of distribution were 4.8 0.6 min,44.4 9.0 min and 0.45 0.11 l/kg ,respectively. Therapeutic plasma levels of 1 ug/ml were maintained upto 2 h. A satisfactory intramuscular dosage regimen would be 3.48 mg/kg and 3.l0mg/kg as priming and maintenaance doses, respectively, to be repeated at 2 h intervals.


How to cite this article:
Uppal R P, Verma S P, Garg S K, Roy R K. Disposition kinetics and dosage regimen of gentamicin in rabbits following intramuscular administration:.Indian J Pharmacol 1992;24:36-37


How to cite this URL:
Uppal R P, Verma S P, Garg S K, Roy R K. Disposition kinetics and dosage regimen of gentamicin in rabbits following intramuscular administration:. Indian J Pharmacol [serial online] 1992 [cited 2020 Nov 28 ];24:36-37
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1992;volume=24;issue=1;spage=36;epage=37;aulast=Uppal;type=0