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Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 109--113

Alpha, adrenoceptors : Are they involved in cardiac arrhythmias induced by intravenous aconitine ?

GP Thomas1, KN Anand2, PM Stephen3 
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2 
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Correspondence Address:
G P Thomas


1. Clonidine (6.25, 12.5 and 25 ęg/kg) and yohimbine (0.25,0.5 and 1 mg/kg) were studied for their effects on aconitine induced cardiac arrhythmias. 2. Initial abnormal rhythm and ventricular tachycardia were induced by intravenous infusion of aconitine in rats. 3. Pretreatment with doses of clonidine and yohimbine which are selective to (( adrenoceptors failed to alter time of onset of initial arrhythmia and ventricular tachycardia, whereas quinidine (10 mg/kg) exhibited significant antiarrhythmic effect by delaying the time of onset of both the arrhythmic stages.


How to cite this article:
Thomas G P, Anand K N, Stephen P M. Alpha, adrenoceptors : Are they involved in cardiac arrhythmias induced by intravenous aconitine ?.Indian J Pharmacol 1991;23:109-113


How to cite this URL:
Thomas G P, Anand K N, Stephen P M. Alpha, adrenoceptors : Are they involved in cardiac arrhythmias induced by intravenous aconitine ?. Indian J Pharmacol [serial online] 1991 [cited 2021 Jan 27 ];23:109-113
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1991;volume=23;issue=2;spage=109;epage=113;aulast=Thomas;type=0