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Year : 1989  |  Volume : 21  |  Issue : 3  |  Page : 73--80

Some pharmacokinetic aspects of sulphacetamide, sulphadimidine and sulphanilamide in West-African Dwarf (WAD) goats

SN Shetty1, IU Asuzu2 
1 
2 

Correspondence Address:
S N Shetty


1. Pharmacokinetic studies of sulphacetamide (SAC), sulphadimidine (SDM) and sulphanilamide (SNL) were conducted in West African Dwarf (WAD) goats injected iv at dose rate of 50 mg/kg. 2. The semilogarithmic graph of plasma concentration-time profile of these sulphonamides exhibited biphasic decline suggestive of 2-compartment open model kinetics. 3. The mean elimination half life of SAC and SNL, was 1.88 and 4.39 h respectively; however, it was 3.04 and 11.06 h respectively for goats with fast and slow SDM-disposition. 4. The respective apparent volume of distribution, Vd (area) of SAC and SNL was 0.87 and 0.48 l/kg; for SDM it was 0.33 and 0.29 l/kg for animals with fast and slow SDM disposition. 5. The approximate degree of in vitro and in vivo binding of SAC (12-16%) and SNL (22- 24%) to plasma protein was independent of drug concentration whereas that of SDM showed inverse relationship with drug concentration (40 and 60% binding with 300 and 10 ęg/ml).


How to cite this article:
Shetty S N, Asuzu I U. Some pharmacokinetic aspects of sulphacetamide, sulphadimidine and sulphanilamide in West-African Dwarf (WAD) goats.Indian J Pharmacol 1989;21:73-80


How to cite this URL:
Shetty S N, Asuzu I U. Some pharmacokinetic aspects of sulphacetamide, sulphadimidine and sulphanilamide in West-African Dwarf (WAD) goats. Indian J Pharmacol [serial online] 1989 [cited 2021 Sep 24 ];21:73-80
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1989;volume=21;issue=3;spage=73;epage=80;aulast=Shetty;type=0