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|Year : 1985 | Volume
| Issue : 4 | Page : 201--204
Influence of diazepam and its solvent on the effect of neuromuscular blocking agents
MI Bhatt1, BG Patel2, KC Dave3
1. The effect of commercially available solution of diazepam and its solvent was investigatedon frog rectus abdominis muscle and sciatic nerve-gastrornemius muscle preparation of-dog.
2. Diazepam and diazepam solvent both equally potentiated acetylcholine induced contracture and both also partially but equally antagonized gallamine induced inhibition of acetylcholine contracture on isolated rectus abdominis muscle of frog.
3. Diazepam and diazepam solvent both antagonized gallamine induced blockade, while augmented that produced by succinylcholine on the sciatic nerve gastrocnemius muscle preparation of dog.
4. The present study suggests that decurarizing effect of commercially available solution of diazepam reported earlier is not of diazepam itself but of its solvent only.
M I Bhatt
|How to cite this article:|
Bhatt M I, Patel B G, Dave K C. Influence of diazepam and its solvent on the effect of neuromuscular blocking agents.Indian J Pharmacol 1985;17:201-204
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Bhatt M I, Patel B G, Dave K C. Influence of diazepam and its solvent on the effect of neuromuscular blocking agents. Indian J Pharmacol [serial online] 1985 [cited 2021 Jul 25 ];17:201-204
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1985;volume=17;issue=4;spage=201;epage=204;aulast=Bhatt;type=0