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Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 189--195

Chlorpromazine induced inhibition of pinnal reflex in mice: involvement of central dopaminergic system

PP Singh1, AY Junnarkar2, DR Shridhar3 
1 
2 
3 

Correspondence Address:
P P Singh


Chlorpromazine (CPZ) inhibited the pinnal reflex in mice in a dose dependent manner. Studies were conducted using agents influencing adrenegric and dopaminergic systems in order to study the mechanism of action. Reserpine, alpha-methyl-p-tyrosine, 6-hydroxydopamine and yohimbine blocked the inhibition of pinnal reflex induced by CPZ. None of the interacting agents had any per se effect on the pinnal reflex. Phenoxy-benzamine, phentolamine and propranolol did not alter the CPZ induced inhibition of pinnal reflex. Imipramine, a rettptake blocker of noradrenaline, did not potentiate the effect of the sub-minimal dose of CPZ. However, sub minimal effect of CPZ on pinnal reflex was potentiated by diethyldithiocarbamate and also by a higher but not by a lower dose of apomorphine. Haloperidol blocked the CPZ induced inhibition of the pinnal reflex. The results suggest that the chlorpromazine-induced inhibition of the pinnal reflex is central in origin and mediated by dopamine at the postsynaptic dopaminergic receptors.


How to cite this article:
Singh P P, Junnarkar A Y, Shridhar D R. Chlorpromazine induced inhibition of pinnal reflex in mice: involvement of central dopaminergic system.Indian J Pharmacol 1983;15:189-195


How to cite this URL:
Singh P P, Junnarkar A Y, Shridhar D R. Chlorpromazine induced inhibition of pinnal reflex in mice: involvement of central dopaminergic system. Indian J Pharmacol [serial online] 1983 [cited 2020 Nov 25 ];15:189-195
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=3;spage=189;epage=195;aulast=Singh;type=0