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Year : 1983  |  Volume : 15  |  Issue : 2  |  Page : 107--110

Response of the goat trachea to some autonomic drugs

S Kulshrestha1, SS Misra2, AL Sharma3, P Sharma4, D Singhal5 
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S Kulshrestha


Goat isolated trachea contracted to acetylcholine, histamine and barium chloride in a dose-dependent manner and to 5-hydroxytryptamine in a narrow dose range. Pheniramine blocked contractions to histamine while cimetidine potentiated. Atropine and cyproheptadine antagonised the contractions of acetylcholine and 5-hydroxytryptamine respectively. The relaxatory responses to epinephrine and isoprenaline were blocked by propranolol. These observations suggest the presence of both H1-excitatory and H2-inhibitory receptors for histamine, excitatory tryptamine and muscarinic receptors for 5-hydroxytryptamine and atropine and -adrenergic receptors.


How to cite this article:
Kulshrestha S, Misra S S, Sharma A L, Sharma P, Singhal D. Response of the goat trachea to some autonomic drugs.Indian J Pharmacol 1983;15:107-110


How to cite this URL:
Kulshrestha S, Misra S S, Sharma A L, Sharma P, Singhal D. Response of the goat trachea to some autonomic drugs. Indian J Pharmacol [serial online] 1983 [cited 2021 Sep 23 ];15:107-110
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=2;spage=107;epage=110;aulast=Kulshrestha;type=0