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|Year : 1983 | Volume
| Issue : 2 | Page : 107--110
Response of the goat trachea to some autonomic drugs
S Kulshrestha1, SS Misra2, AL Sharma3, P Sharma4, D Singhal5
Goat isolated trachea contracted to acetylcholine, histamine and barium chloride in a dose-dependent manner and to 5-hydroxytryptamine in a narrow dose range. Pheniramine blocked contractions to histamine while cimetidine potentiated. Atropine and cyproheptadine antagonised the contractions of acetylcholine and 5-hydroxytryptamine respectively. The relaxatory responses to epinephrine and isoprenaline were blocked by propranolol.
These observations suggest the presence of both H1-excitatory and H2-inhibitory receptors for histamine, excitatory tryptamine and muscarinic receptors for 5-hydroxytryptamine and atropine and á-adrenergic receptors.
|How to cite this article:|
Kulshrestha S, Misra S S, Sharma A L, Sharma P, Singhal D. Response of the goat trachea to some autonomic drugs.Indian J Pharmacol 1983;15:107-110
|How to cite this URL:|
Kulshrestha S, Misra S S, Sharma A L, Sharma P, Singhal D. Response of the goat trachea to some autonomic drugs. Indian J Pharmacol [serial online] 1983 [cited 2021 Sep 23 ];15:107-110
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=2;spage=107;epage=110;aulast=Kulshrestha;type=0