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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 345--350

Preliminary observation regarding the cataleptogenic activity of maprotiline in the mouse

JJ Balsara1, VR Mane2, VP Gada3, NV Nandal4, AG Chandorkar5 
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Correspondence Address:
J J Balsara


Maprotiline (5-40 mg/kg ip) was found to induce catalepsy in mice. Treatment with apomorphine (2.5 and 5 mg/kg. ip) and atropine (20 mg/kg, ip) significantly reduced the cataleptic effect of maprotiline. Further, pretreatment with maprotiline (2.5-10 mg/kg, ip) significantly antagonised apomorphine-induced cage climbing behaviour in mice. The results suggest that the cataleptogenic effect of maprotiline is probably due to blockade of post-synaptic striatal dopamine receptors.


How to cite this article:
Balsara J J, Mane V R, Gada V P, Nandal N V, Chandorkar A G. Preliminary observation regarding the cataleptogenic activity of maprotiline in the mouse.Indian J Pharmacol 1982;14:345-350


How to cite this URL:
Balsara J J, Mane V R, Gada V P, Nandal N V, Chandorkar A G. Preliminary observation regarding the cataleptogenic activity of maprotiline in the mouse. Indian J Pharmacol [serial online] 1982 [cited 2020 Nov 28 ];14:345-350
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1982;volume=14;issue=4;spage=345;epage=350;aulast=Balsara;type=0