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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 319--323

Effect of Mk-212 on isolated guinea-pig heart

UP Patel1, RK Goyal2, SC Verma3 
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2 
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Correspondence Address:
U P Patel


MK-212 ; (6-Chloro-2-(1-piperazinyl)-pyrazine) (5x 10-8 to 4x10-7M) produced dose-dependent positive inotropic effects on guinea-pig heart. The responses to MK-212 were competitively blocked by mepyramine maleate and cyproheptadine. Metiamide did not alter the resonses to MK-212 on guinea-pig heart.The responses to MK-212 were also Inhibited competitively by propranolol. Reserpinization inhibited the responses to MK-212 completely. Our findings suggest that, MK-212 induced positive inotropic effect in guinea-pig heart 18 due to stimulation of post-syoaptic beta-receptors, involving the release of noradrenaline which follows the stimulation of either presynaptic serotonin or H1- histamine receptors.


How to cite this article:
Patel U P, Goyal R K, Verma S C. Effect of Mk-212 on isolated guinea-pig heart.Indian J Pharmacol 1982;14:319-323


How to cite this URL:
Patel U P, Goyal R K, Verma S C. Effect of Mk-212 on isolated guinea-pig heart. Indian J Pharmacol [serial online] 1982 [cited 2021 Jan 15 ];14:319-323
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1982;volume=14;issue=4;spage=319;epage=323;aulast=Patel;type=0