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Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 277--280

Modification of glibenclamide hypoglycaemia by some antihypertensive agents in rabbits

H Mishra1, B Gupta2, KK Saxena3, VK Kulshrestha4, DN Prasad5 
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H Mishra


Chlorthalidone ( 3.0 mg.kg, ), hydrochlorthiazide ( 3.0 mg/kg ), frusemide (1 .0 mg/kg) and clonidine (0.003 mg/kg) did not have any per se effect on fasting blood sugar level of rabbits up to 5 h.When clonidine was administered along with glibenclamide (0.024 mg/kg), it not only caused early onset of hypoglycaemia but also Produced greater fall in blood sugar than observed with glibenclamide alone. The diuretics did not modify the hypoglycaemic activity of glibenclamide.


How to cite this article:
Mishra H, Gupta B, Saxena K K, Kulshrestha V K, Prasad D N. Modification of glibenclamide hypoglycaemia by some antihypertensive agents in rabbits.Indian J Pharmacol 1982;14:277-280


How to cite this URL:
Mishra H, Gupta B, Saxena K K, Kulshrestha V K, Prasad D N. Modification of glibenclamide hypoglycaemia by some antihypertensive agents in rabbits. Indian J Pharmacol [serial online] 1982 [cited 2020 Dec 4 ];14:277-280
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1982;volume=14;issue=3;spage=277;epage=280;aulast=Mishra;type=0