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Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 199--201

Comparison of total alkaloids of Tylophora indica and disodium cromoglycate on mast cell stabilization

VS Geetha1, S Viswanathan2, L Kameswaran3 
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Correspondence Address:
V S Geetha


The total alkaloids of Tylophora indica were tested for mast cell stabilising effect in comparison with disodium cromoglycate by challenging against three different mast cell degranulators, diazoxide, carbachol and polymixin B, in vitro. Both tylophora alkaloids and disodium cromoglycate prevented in similar concentrations, the mast cell degranulation occurring with diazoxide alone. Tylophora alkaloids and disodium cromoglycate did not significantly affect the carbachol and ploymyxim induced degranulation of mast cells. The results suggest that Tylophora alkaloids may have similar mechanism of action as disodium cromoglycate through cyclic AMP.


How to cite this article:
Geetha V S, Viswanathan S, Kameswaran L. Comparison of total alkaloids of Tylophora indica and disodium cromoglycate on mast cell stabilization.Indian J Pharmacol 1981;13:199-201


How to cite this URL:
Geetha V S, Viswanathan S, Kameswaran L. Comparison of total alkaloids of Tylophora indica and disodium cromoglycate on mast cell stabilization. Indian J Pharmacol [serial online] 1981 [cited 2020 Oct 20 ];13:199-201
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1981;volume=13;issue=2;spage=199;epage=201;aulast=Geetha;type=0