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Year : 1980  |  Volume : 12  |  Issue : 1  |  Page : 27--30

Effect of phenobarbitone pretreatment on tolbutamide half life in cases of hepatic cirrhosis

D Singh1, R Vijayavargiya2, P Mehta3, AL Kakrani4 
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Correspondence Address:
D Singh


. One gram of sodium tolbutamide was administered orally to twenty-five patients with hepatic cirrhosis and five normal subjects and its serial plasma levels were measured both before and after phenobarbital pretreatment. Phenobarbital administration reduced the enhanced half life (t1/2) of tolbutamide in nonsmokers with hepatic cirrhosis but no significant alteration was produced in smokers with hepatic cirrhosis.


How to cite this article:
Singh D, Vijayavargiya R, Mehta P, Kakrani A L. Effect of phenobarbitone pretreatment on tolbutamide half life in cases of hepatic cirrhosis.Indian J Pharmacol 1980;12:27-30


How to cite this URL:
Singh D, Vijayavargiya R, Mehta P, Kakrani A L. Effect of phenobarbitone pretreatment on tolbutamide half life in cases of hepatic cirrhosis. Indian J Pharmacol [serial online] 1980 [cited 2020 Oct 27 ];12:27-30
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1980;volume=12;issue=1;spage=27;epage=30;aulast=Singh;type=0