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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 265--268

Investigations into the positive inotropic effect of ST 600 [2-(5-fluoro-O-toluidine)-2-imidazoline hydrochloride] on isolated hearts

A Veeranjaneyulu1, SC Verma2 
1 
2 

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A Veeranjaneyulu


. ST 600 [2-(5 fluoro-O-toluidine)-2 imidazoline hydrochloride] in doses 2.5 to 40 ęg injected into the isolated perfused guineapig heart caused an increase in contractile force. The effects of ST 600 were blocked by metiamide (3x 10-5M). Mepyramine or reserpine treatment (5mg/kg i.p.; 24 h prior to the experiment) did not influence the contractile effects of ST 600. Clonidine and ST 600 both produced parallel dose-response curves, which were competitively antagonized by H1-receptor antagonists burimamide and metiamide respectively. It is suggested that the inotropic action of ST 600 is due to stimulation of histamine H2-receptors.


How to cite this article:
Veeranjaneyulu A, Verma S C. Investigations into the positive inotropic effect of ST 600 [2-(5-fluoro-O-toluidine)-2-imidazoline hydrochloride] on isolated hearts.Indian J Pharmacol 1979;11:265-268


How to cite this URL:
Veeranjaneyulu A, Verma S C. Investigations into the positive inotropic effect of ST 600 [2-(5-fluoro-O-toluidine)-2-imidazoline hydrochloride] on isolated hearts. Indian J Pharmacol [serial online] 1979 [cited 2020 Nov 24 ];11:265-268
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=4;spage=265;epage=268;aulast=Veeranjaneyulu;type=0