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Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 171--173

Effect of cyproheptadine on ascorbic acid uptake by bone in vitro

SL Sarkar1, KV Jogi2, A Mohimen3 
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Correspondence Address:
S L Sarkar


. Ascorbic acid uptake of homogenised long bone of rats was estimated after 21/2h incubation in Ringer phosphate bicarbonate buffer (pH 7.4) containing 0,1,25,50,100,200 ng/ml cyproheptadine. In a similar experiment, ascorbic acid uptake was estimated in the presence of 25 ng/ml serotonin and a combination of 25 ng/ml each of serotonin and eyproheptadine. Cyproheptadine 25, 50 and 100 ng/ml significantly increased ascorbic acid uptake. while with 200 ng/ml the uptake was significantly reduced. Although serotonin per se did not affect the uptake of ascorbic acid, it inhibited cyproheptadine induced increase in ascorbic acid uptake.


How to cite this article:
Sarkar S L, Jogi K V, Mohimen A. Effect of cyproheptadine on ascorbic acid uptake by bone in vitro.Indian J Pharmacol 1978;10:171-173


How to cite this URL:
Sarkar S L, Jogi K V, Mohimen A. Effect of cyproheptadine on ascorbic acid uptake by bone in vitro. Indian J Pharmacol [serial online] 1978 [cited 2021 Jan 16 ];10:171-173
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1978;volume=10;issue=2;spage=171;epage=173;aulast=Sarkar;type=0