|
 |
| LETTER TO THE EDITOR |
|
|
|
| Year : 2022 | Volume
: 54
| Issue : 2 | Page : 153 |
| |
Role of Vitamin D in COVID-19: Correspondence
Pathum Sookaromdee1, Viroj Wiwanitkit2
1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India
| Date of Submission | 26-Nov-2021 |
| Date of Decision | 10-Jan-2022 |
| Date of Acceptance | 22-Mar-2022 |
| Date of Web Publication | 10-May-2022 |
Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, 11 Bangkok 112 Bangkok 103320
Thailand
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijp.ijp_897_21
How to cite this article:
Sookaromdee P, Wiwanitkit V. Role of Vitamin D in COVID-19: Correspondence. Indian J Pharmacol 2022;54:153 |
Sir,
We would like to share ideas on “Evidences suggesting a possible role of Vitamin D in COVID 19: The missing link.”[1] Singh et al. concluded that “Using Vitamin D as prophylaxis and/or chemotherapeutic treatment … of Vitamin D affecting many people worldwide.”[1] We agree that Vitamin D might play a role in the management of COVID-19. Trials might be useful. Considering trial, some important concerns are hereby discussed. First, it should assess the impact of genetic polymorphism. Vitamin D-binding protein polymorphism might be associated with outcome of Vitamin D supplementation in the COVID-19 treatment.[2] Additionally, if a trial will be performed, a background Vitamin D data of subjects should be assessed.
The effect of Vitamin D in COVID-19 might also be associated with some other modifiers. Sunlight exposure and estrogen interaction should be discussed. Estradiol is also proposed for its usefulness in managing COVID-19.[3] There might be an interesting co-advantage of both Vitamin D and estradiol in the management of COVID-19.
Financial support and sponsorship
Nil.
Conflicts of interest
The authors ask for waiving for any charge for this correspondence.
| » References | |  |
| 1. | Singh S, Singh CM, Ranjan A, Kumar S, Singh DK. Evidences suggesting a possible role of Vitamin D in COVID 19: The missing link. Indian J Pharmacol 2021;53:394-402.  [ PUBMED] [Full text] |
| 2. | Speeckaert MM, Delanghe JR. The potential significance of vitamin D binding protein polymorphism in COVID-19. Int J Infect Dis 2021;109:90. |
| 3. | Youn JY, Zhang Y, Wu Y, Cannesson M, Cai H. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol 2021;46:102099. |
|
