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 » Introduction
 » Methods
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 Table of Contents    
SYSTEMATIC REVIEW AND META-ANALYSIS
Year : 2021  |  Volume : 53  |  Issue : 6  |  Page : 493-498
 

Chemoprophylaxis against COVID-19 among health-care workers using Ivermectin in low- and middle-income countries: A systematic review and meta-analysis


1 Department of Medicine, Endocrinology Unit, University College Hospital, Ibadan, Nigeria
2 Department of Medicine, Infectious Diseases Unit, College of Medicine and Allied Health Sciences, Freetown, Sierra Leone
3 Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
4 Department of Medicine, University College Hospital, Ibadan, Nigeria
5 Department of Family Medicine, University College Hospital, Ibadan, Nigeria

Date of Submission13-Feb-2021
Date of Decision19-May-2021
Date of Acceptance26-Nov-2021
Date of Web Publication30-Dec-2021

Correspondence Address:
Dr. Taoreed Adegoke Azeez
Department of Medicine, Endocrinology Unit, University College Hospital, Ibadan
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.ijp_117_21

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 » Abstract 


Coronavirus disease-2019 (COVID-19) is a novel viral infectious disease that the World Health Organization (WHO) has announced to be a pandemic. This meta-analysis was aimed at providing evidence for the use of ivermectin to prevent COVID-19 among hospital workers in low-resource countries. Medical databases including African Journals online, Google Scholar, PubMed, Cochrane library, EMBASE, COVID-19 research database (WHO), Clinicaltrials.gov, and SCOPUS were searched for studies on Ivermectin as a chemoprophylactic drug against COVID-19 among hospital personnel in settings with limited resources. Preprint servers such as bioRxiv and medRxiv as well as the gray literature were also searched. Studies adjudged to be eligible were identified using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses algorithm. Statistical analyses were done using Stata version 14.3. Seven studies were selected for the meta-analysis. The total sample size was 2652. There were two randomized controlled trials and five nonrandomized studies. Some studies dosed Ivermectin daily while some dosed it weekly. However, one of the studies dosed it monthly. The studies reported variable clinical benefits. I2 statistic was 92%, and random effect model was used. The pooled odd ratio was 0.11 (95% confidence interval 0.09–0.13). This implies that 89% of the participants benefited from taking Ivermectin as a form of preexposure chemoprophylaxis. Ivermectin has a significant clinical benefit as a preventive drug against COVID-19 for hospital personnel in settings with limited resources.


Keywords: Chemoprophylaxis, coronavirus disease-2019 prevention, health-care workers, Ivermectin, resource-limited settings


How to cite this article:
Azeez TA, Lakoh S, Adeleke AA, Balogun OT, Olanipekun BJ, Olusola FI. Chemoprophylaxis against COVID-19 among health-care workers using Ivermectin in low- and middle-income countries: A systematic review and meta-analysis. Indian J Pharmacol 2021;53:493-8

How to cite this URL:
Azeez TA, Lakoh S, Adeleke AA, Balogun OT, Olanipekun BJ, Olusola FI. Chemoprophylaxis against COVID-19 among health-care workers using Ivermectin in low- and middle-income countries: A systematic review and meta-analysis. Indian J Pharmacol [serial online] 2021 [cited 2023 Sep 23];53:493-8. Available from: https://www.ijp-online.com/text.asp?2021/53/6/493/334348





 » Introduction Top


Coronavirus disease-2019 (COVID-19), commonly abbreviated as COVID-19, is a newly documented infectious disease caused by a beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).[1] It was first reported in Wuhan in China but has now affected all the continents of the world.[2] It has affected several millions of individuals in the world causing significant number of deaths including those of healthcare workers too.[3] The impact of COVID-19 in low- and middle-income countries is unique because there are shortages of health-care workers, well-equipped health facilities, and personal protective equipment.[4]

The World Health Organization (WHO) has defined health-care workers as people whose job is to protect and improve the health of their communities.[5] Ethically, health-care workers cannot refuse to treat patients simply because they are at risk of contracting the patients' diseases.[6] Even during lockdowns when people are expected to stay at home to minimize the spread of infections, health-care workers must still go the health-care facilities to treat infected patients and this put them at high risk of getting infected. Therefore, the safety of health-care workers is of crucial importance especially in low-resource settings where there is background insufficiency of health-care workforce and personal protective equipment.[7]

Studies have shown that there is an increased risk of COVID-19 infection among hospital personnel and the members of their household.[8],[9],[10] Over 10,000 and 500,000 health-care workers have been infected with COVID-19 in Africa and the Americas, respectively, and similar figures have been estimated in other regions.[11],[12],[13] Interestingly, a study documented that infection rate among health-care workers was still higher than the general population despite the use of personal protective devices.[9] This suggests that health-care workers need additional protection to reduce the risk of contracting COVID-19.

A number of vaccines to protect against COVID-19 have been approved for usage in various countries, and more vaccines are still undergoing trials.[14],[15] Statistics have however shown that COVID-19 vaccination has the lowest rate of coverage in nations with low or middle income.[16] This unequitable access to the vaccines has also been emphasized by the WHO with the aim of improving access worldwide.[17] All these shortcomings have heightened the research on suitable candidates for chemoprophylaxis. Currently, there is inadequate evidence to recommend any agent as an ideal chemoprophylactic drug for COVID-19.[18] Chloroquine and hydroxychloroquine were initially suggested as being beneficial for preexposure prophylaxis against COVID-19, but there is a dearth of concrete clinical data to support the initial suggestion.[19] As a result, attention has now been shifted to other drugs such as Ivermectin.

Historically, Ivermectin was discovered by Satoshi Omura and William C. Campbell and this culminated into the award of the 2015 Nobel prize to the two of them for their works.[20] Ivermectin is a semi-synthetic macrocyclic lactone derivative of avermectin with microfilaicidal properties.[21] It was approved for the treatment of river blindness, and it has been extremely beneficial in the control of the disease in sub-Saharan Africa.[22] The widespread human usage derives from the beneficial properties of the drug such as efficacy, broad-spectrum anti-parasitic action, safety profile, ease of administration, and tolerability.[23] Ivermectin inhibits glutamate-gated chloride channels in the filarial worms, thereby paralyzing their muscles, but this effect is not seen in humans.[23] The half-life of Ivermectin in humans is 24–36 h, and some of the active metabolites persist for up to 3–4 days.[23] Although Ivermectin was originally approved for onchocerciasis, it has proven to be effective in the treatment of strongyloidiasis, scabies, leishmaniasis, and myiasis.

In a study involving over 3000 patients with onchocerciasis, some of the other beneficial side effects of Ivermectin reported were improved appetite, enhanced libido in men, restoration of menstrual flow in some cases of secondary amenorrhea, and reduced arthritic joint pains.[21] Some of the documented adverse effects of Ivermectin are headache, allergic reactions, postural dizziness, worsened pruritus, chest pain, confusion, seizure, and loss of consciousness.[24] Interestingly, Ivermectin has been documented to have drug–drug interactions with certain medications such as barbiturates, benzodiazepines, and valproic acid. It crosses the placenta and passes into the breast milk making it unsafe in pregnancy and during lactation.[25]

In vitro studies have demonstrated a broad antiviral properties of ivermectin, but there limited clinical studies to justify their antiviral indication in humans.[26] Before COVID-19 pandemic, the various viruses that Ivermectin has been demonstrated to inhibit in vitro include Zika virus, Dengue virus, yellow fever virus, human immunodeficiency virus type 1, and avian influenza virus.[27],[28],[29],[30] The suppressive effect of Ivermectin on the replication of these ribonucleic acid viruses lies in its ability to inhibit α/β-importin which is essential for the transport of viral proteins from the cytoplasm to the nucleus.[31]

Caly et al. have demonstrated the potent inhibitory effect of Ivermectin on SARS-CoV-2 replication in vitro.[32] This has led to a lot of clinical trials on the therapeutic effect of Ivermectin on COVID-19, and the results have been impressive.[33],[34],[35],[36] The mechanism by which Ivermectin treats COVID-19 is still a subject of intense research. However, the proposed mechanism is the ability of Ivermectin to inhibit transport of viral proteins from the cytoplasm to the nucleus.[37] This hypothesized mechanism is illustrated in [Figure 1].
Figure 1: Ivermectin suppresses severe acute respiratory syndrome coronavirus-2 entrance into the nucleus for replication by inhibiting α/β-importin

Click here to view


This meta-analysis was aimed at critically examining the studies on preexposure prophylaxis of COVID-19 with Ivermectin done in low and middle income countries so as to guide its recommendation for health workers in these settings where vaccines are not readily available.


 » Methods Top


Search strategy and selection processes.

Relevant studies on preexposure prophylaxis of COVID-19 done in resource-limited settings were searched on medical databases including African Journals online, Google Scholar, PubMed, Cochrane library, EMBASE, COVID-19 research database (WHO), Clinicaltrials.gov, and SCOPUS. Preprint servers such as bioRxiv and medRxiv were also searched. The search terms used were “Ivermectin,” “prophylaxis,” “prevention,” and “COVID-19.” Other terms used in the data search included “Ivermectin use in COVID-19,” “mechanism of action of Ivermectin,” “Pre-exposure prophylaxis of COVID-19,” and “pre-exposure chemoprophylaxis of COVID-19 in resource-limited settings with Ivermectin.” Boolean operators such as “AND” as well as “OR” were also used to enhance the quality and quantity of the available studies. The gray literature was also searched in order to improve the studies available for the meta-analysis. The literature search and selection of studies were done by strictly following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PRISMA flow diagram is shown in [Figure 2].
Figure 2: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram of the literature search and selection

Click here to view


Inclusion criteria

  1. Studies done to demonstrate the chemoprophylactic effect of Ivermectin on COVID-19
  2. Studies done in countries with low or middle income, going by the definition adopted by the World Bank[38] and whose abstracts with or without full text were available at the searched databases or from the gray literature.


Exclusion criteria

  1. Studies on prophylaxis of COVID-19 with Ivermectin outside low- and middle-income countries.[34]
  2. Studies on Ivermectin use in low- and middle-income countries but not focusing on the chemoprophylactic usage.


Data collection and analysis

Abstracts and full texts were carefully examined independently by the authors. Disagreements were resolved by consensus. Data extracted were study designs, interventions and controls, outcome variables, ethical considerations, and reported conflicts of interest. The main outcome variable of interest was the odds of being infected with COVID-19 when taking Ivermectin as chemoprophylaxis compared with placebo (odds ratio [OR] and 95% confidence interval [CI]). CI was calculated for studies where it was not given. Data extracted were initially obtained on a spreadsheet before it was transferred to a statistical tool. The Newcastle-Ottawa scale was used to assess the quality and bias of the nonrandomized studies while the Cochrane Risk of Bias tool was used to assess bias in the randomized trials. Statistical analyses were done using Stata version 14.3 manufactured by Stata Corp LLC, College Station, Texas, USA. DerSimonian and Laird random effect model was used. Heterogeneity was assessed using the I2 statistic.


 » Results Top


Seven studies were eventually selected, having met the eligibility criteria, for the meta-analysis. [Table 1] shows the locations and sample size of each study. There were two randomized controlled trials and five nonrandomized studies. Two of the studies were done in Africa and Asia, respectively, and three studies were conducted in South America. [Table 2] shows the protocol used in each study to administer Ivermectin. Some studies dosed Ivermectin daily while some dosed it weekly. However, one of the studies dosed it monthly. [Table 3] shows the ORs and the pooled OR. The total sample size in this meta-analysis was 2652. I2 statistic was 92% which suggests significant heterogeneity in the selected studies. Using random effect model, on account of the significant heterogeneity, the pooled odd ratio was 0.11 (95% CI 0.09–0.13). This implies that 89% of the participants benefited from taking Ivermectin as a form of preexposure chemoprophylaxis. The forest plot is shown in [Figure 3].
Table 1: Studies, types and locations

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Table 2: Studies and ivermectin doses

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Table 3: The sample size, odds ratio of each study

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Figure 3: Forest plot of the meta-analysis

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 » Discussion Top


There were limited numbers of studies available for this meta-analysis. Camprubí et al.[45] have also highlighted the dearth of clinical studies on the possible repurposing of Ivermectin as a therapeutic or prophylactic drug against COVID-19.[44] All the studies showed variable benefit of using Ivermectin as chemoprophylaxis against COVID-19. However, most of the studies were not randomized controlled trials. Bonsu et al.,[46] have reported the logistic and financial hurdles encountered in conducting drug trials in resource limited settings, thereby limiting the number of published randomized clinical trials from such settings. There was significant heterogeneity in the studies. This could be due to the differences in demographics and study designs. Six of the studies involved health-care workers while a study involved relatives of COVID-19 patients who were caring for their infected relatives.

This meta-analysis shows that 89% of the individuals in the various studies, when pooled together, would benefit from the usage of Ivermectin to prevent COVID-19 infection. The findings in this study are similar to that of another meta-analysis that looked at the clinical benefit of Ivermectin as either a therapeutic or prophylactic agent across all settings, both resource-limited and developed nations.[47] In that study, 90% of the individuals (both health workers and the general population) who took various doses of Ivermectin as chemoprophylaxis benefited from it. This is quite significant for hospital personnel in settings where the resources are inadequate. Such settings are characterized by high incidence of COVID-19 infections among the limited health workers, yet protective wears are in limited supply and approved vaccines are still not readily available.

Limitations

The available articles selected for this study were few and highly heterogeneous. In addition, most of the studies were not randomized controlled drug trials and the risk of bias was quite high. Furthermore, the doses of Ivermectin varied across studies


 » Conclusion Top


Our study has demonstrated the effectiveness of Ivermectin in preventing the transmission of the SARS-CoV-2 among health-care workers in low- and middle-income countries. In addition, the various doses were all found to be effective, but the most effective was the 12 mg weekly doses administered over a period of 8 weeks. With the limited access to COVID-19 vaccines and sustainable supplies of infection prevention commodities, we recommend that Ivermectin may be used as a prophylactic drug against COVID-19 among hospital workers practicing in developing countries. Notwithstanding the need for further randomized studies on the use of Ivermectin as preventive therapy.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
 » References Top

1.
Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, et al. COVID-19: Immunopathogenesis and immunotherapeutics. Signal Transduct Target Ther 2020;5:128.  Back to cited text no. 1
    
2.
Pawar M. The global impact of and responses to COVID-19 pandemic. Int J Community Soc Dev 2020;2:111-20.  Back to cited text no. 2
    
3.
Du RH, Liang LR, Yang CQ, Wang W, Cao TZ, Li M, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A prospective cohort study. Eur Respir J 2020;55:2000524.  Back to cited text no. 3
    
4.
Bong CL, Brasher C, Chikumba E, McDougall R, Mellin-Olsen J, Enright A. The COVID-19 pandemic: Effects on low- and middle-income countries. Anesth Analg 2020;131:86-92.  Back to cited text no. 4
    
5.
World Health Organization (WHO). Health Workers. Available from: https://www.who.int/whr/2006/06_chap1_en.pdf. [Last accessed on 2021 Feb 05].  Back to cited text no. 5
    
6.
Simonds AK, Sokol DK. Lives on the line? Ethics and practicalities of duty of care in pandemics and disasters. Eur Respir J 2009;34:303-9.  Back to cited text no. 6
    
7.
Huh S. How to train health personnel to protect themselves from SARS-CoV-2 (novel coronavirus) infection when caring for a patient or suspected case. J Educ Eval Health Prof 2020;17:10.  Back to cited text no. 7
    
8.
Shah AS, Wood R, Gribben C, Caldwell D, Bishop J, Weir A, et al. Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households: Nationwide linkage cohort study. BMJ 2020;371:m3582.  Back to cited text no. 8
    
9.
Nguyen LH, Drew DA, Graham MS, Joshi AD, Guo CG, Ma W, et al. Risk of COVID-19 among front-line health-care workers and the general community: A prospective cohort study. Lancet Public Health 2020;5:e475-83.  Back to cited text no. 9
    
10.
Chou R, Dana T, Buckley DI, Selph S, Fu R, Totten AM. Epidemiology of and risk factors for coronavirus infection in health care workers: A living rapid review. Ann Intern Med 2020;173:120-36.  Back to cited text no. 10
    
11.
World Health Organization Regional Office for Africa. Over 10 000 Healtworkers in Africa Infected with COVID-19. Available from: https://www.afro.who.int/news/over-10-000-health-workers-africa-infected-covid-19. [Last accessed on 2021 Feb 05].  Back to cited text no. 11
    
12.
Pan American Health Organization. COVID-19 has Infected some 570 000 Health Workers and Killed 2500 in the Americas, PAHO Director Says. Available from: https://www.paho.org/en/news/2-9-2020-covid-19-has-infected-some-570000-health-workers-and-killed-2500-americas-paho. [Last accessed on 2021 Feb 05].  Back to cited text no. 12
    
13.
Erdem H, Lucey DR. Healthcare worker infections and deaths due to COVID-19: A survey from 37 nations and a call for WHO to post national data on their website. Int J Infect Dis 2021;102:239-41.  Back to cited text no. 13
    
14.
World Health Organization. The Different Types of COVID-19 Vaccines. Available from: https://www.who.int/news-room/feature-stories/detail/the-race-for-a-covid-19-vaccine-explained. [Last accessed on 2021 Feb 05].  Back to cited text no. 14
    
15.
Global Alliance for Vaccines and Immunizations. The COVID-19 Vaccine Race- Weekly Update. Available from: https://www.gavi.org/vaccineswork/covid-19-vaccine-race. [Last accessed on 2021 Feb 05].  Back to cited text no. 15
    
16.
Ritchie H, Ortiz-Ospina E, Beltekian D, Mathieu E, Hasell J, Macdonald B, et al. Coronavius (COVID-19) Vaccinations. Available from: https://ourworldindata.org/covid-vaccinations. [Last accessed on 2021Feb 05].  Back to cited text no. 16
    
17.
World Health Organization. Global Equitable Access to COVID-19 Vaccines Estimated to Generate to Economic Benefits of at Least US $ 153 Billion in 2020-21 in 10 Major Economies According to the New Report by the Eurasia. Available from: https://www.who.int/news/item/03-12-2020-global-access-to-covid-19-vaccines-estimated-to-generate-economic-benefits-of-at-least-153-billion-in-2020-21. [Last accessed on 2021 Feb 05].  Back to cited text no. 17
    
18.
Jin YH, Zhan QY, Peng ZY, Ren XQ, Yin XT, Cai L, et al. Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version). Mil Med Res 2020;7:41.  Back to cited text no. 18
    
19.
Surendra K, Harsh G, Chandrashekhar B, Lal MB, Manoj M, Ravindra J, et al. Role of hydroxychloroquine and chloroquine in prophlaxis against COVID-19 review study. World J Adv Res Rev 2020;6:170-5.  Back to cited text no. 19
    
20.
Van Voorhis WC, Hooft van Huijsduijnen R, Wells TN. Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 nobel laureates in physiology or medicine. Proc Natl Acad Sci U S A 2015;112:15773-6.  Back to cited text no. 20
    
21.
Anosike JC, Dozie IN, Ameh GI, Ukaga CN, Nwoke BE, Nzechukwu CT, et al. The varied beneficial effects of ivermectin (Mectizan) treatment, as observed within onchocerciasis foci in south-eastern Nigeria. Ann Trop Med Parasitol 2007;101:593-600.  Back to cited text no. 21
    
22.
World Health Organization 2015 Framework for the Establishment of the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN). Available from: https://www.afro.who.int/index.php?option=com_docman&task=doc_download&gid=9782&Itemid=2593. [Last accessed on 2021 Feb 05].  Back to cited text no. 22
    
23.
Crump A, Ōmura S. Ivermectin, 'wonder drug' from Japan: The human use perspective. Proc Jpn Acad Ser B Phys Biol Sci 2011;87:13-28.  Back to cited text no. 23
    
24.
López-Medina E, López P, Hurtado IC, Dávalos DM, Ramirez O, Martínez E, et al. Effect of ivermectin on time to resolution of symptoms among adults with mild COVID-19: A randomized clinical trial. JAMA 2021;325:1426-35.  Back to cited text no. 24
    
25.
González Canga A, Sahagún Prieto AM, Diez Liébana MJ, Fernández Martínez N, Sierra Vega M, García Vieitez JJ. The pharmacokinetics and interactions of ivermectin in humans – A mini-review. AAPS J 2008;10:42-6.  Back to cited text no. 25
    
26.
Heidary F, Gharebaghi R. Ivermectin: A systematic review from antiviral effects to COVID-19 complementary regimen. J Antibiot (Tokyo) 2020;73:593-602.  Back to cited text no. 26
    
27.
Yang SN, Atkinson SC, Wang C, Lee A, Bogoyevitch MA, Borg NA, et al. The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer. Antiviral Res 2020;177:104760.  Back to cited text no. 27
    
28.
Mastrangelo E, Pezzullo M, De Burghgraeve T, Kaptein S, Pastorino B, Dallmeier K, et al. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: New prospects for an old drug. J Antimicrob Chemother 2012;67:1884-94.  Back to cited text no. 28
    
29.
Götz V, Magar L, Dornfeld D, Giese S, Pohlmann A, Höper D, et al. Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import. Sci Rep 2016;6:23138.  Back to cited text no. 29
    
30.
Wagstaff KM, Rawlinson SM, Hearps AC, Jans DA. An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import. J Biomol Screen 2011;16:192-200.  Back to cited text no. 30
    
31.
Angelim CC, Sousa de Brito PK, Dowich GB, Gouvea de Souza F, Rodriguez LR, Guimaraes DM, et al. Use of ivermectin drug for treating COVID-19: Review article. Int J Develop Res 2020;10:42690-2.  Back to cited text no. 31
    
32.
Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res 2020;178:104787.  Back to cited text no. 32
    
33.
Chaccour C, Casellas A, Di-Matteo AB, Pineda I, Fernandez-Montero A, Ruiz-Castillo P, et al. The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double blind, placebo-controlled, randomized clinical trial. EClinicalMedicine 2020;2020:100720.  Back to cited text no. 33
    
34.
Ahmed S, Karim MM, Ross AG, Hossain MS, Clemens JD, Sumiya MK, et al. A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness. Int J Infect Dis 2021;103:214-6.  Back to cited text no. 34
    
35.
Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter J. Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019. Chest Infect 2021;159:85-92.  Back to cited text no. 35
    
36.
Babalola OE, Bode CO, Ajayi AA, Alakaloko FM, Akase IE, Otrofanowei E, et al. Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind, dose-response study in Lagos. QJM 2021:hcab035. [ahead of print]. Available from: https://www.medrxiv.org/content/10.1101/2021.01.05.21249131v1. [Last accessed on 2021 Feb 06].  Back to cited text no. 36
    
37.
Gupta D, Sahoo AK, Singh A. Ivermectin: Potential candidate for the treatment of COVID 19. Braz J Infect Dis 2020;24:369-71.  Back to cited text no. 37
    
38.
World Bank. The World Bank in Middle Income Countries. Available from: https://www.worldbank.org/en/country/mic/overview. [Last accessed on 2021 Feb 06].  Back to cited text no. 38
    
39.
Alam MT, Murshed R, Gomes PF, Masud Z, Saber S, Chaklader MA, et al. Ivermectin as pre-exposure prophylaxis for COVID-19 among healthcare providers in a selected tertiary hospital in Dhaka – An observational study. Eur J Med Health Sci 2020;2:599.  Back to cited text no. 39
    
40.
Elgazzar A, Hany B, Yousef SO, Hafez M, Moussa H, AbdelAziz E. Efficacy and safety of ivermectin for treatment and prophylaxis of COVID-19 pandemic. Res Sq 2020. [doi: 10.21203/rs. 3, rs-100956/v2].  Back to cited text no. 40
    
41.
Behera P, Patro BK, Singh AK, Chandanshive PD, Kumar R, Pradhan SK, et al. Role of ivermectin in the prevention of COVID-19 infection among health care workers in India: A matched case-control study. PLoS one; 16(2): e0247123 doi: 10.1371/journal.pone.0247163. eCollection 2021.  Back to cited text no. 41
    
42.
Shouman W, Hegazy AA, Nafae RM, Ragab M. Use of ivermectin as a potential chemoprophylaxis for COVID-19: A randomized clinical trial. J Clin Diagn Res 2021;15:27-32.  Back to cited text no. 42
    
43.
Chala ER. Prophylaxis COVID-19 in healthcare agents by intensive treatment with ivermectin and iota-carrageenan (IvercarTuc). Available from: https://www.clinicaltrials.gov/ct2/show/NCT04701710. [Last accessed on 2021 Feb 03].  Back to cited text no. 43
    
44.
Carvallo H, Hirsch R, Alkis P, Contreras V. Study of the efficacy and safety of topical ivermectin and iota-carrageenan in the prophylaxis against COVID-19 in health personnel. J Biomed Res Clin Invest 2020;2:1007.  Back to cited text no. 44
    
45.
Camprubí D, Almuedo-Riera A, Martí-Soler H, Soriano A, Hurtado JC, Subirà C, et al. Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients. PLoS One 2020;15:e0242184.  Back to cited text no. 45
    
46.
Bonsu JM, Frasso R, Curry AE. Lessons from the field: The conduct of randomized controlled trials in Botswana. Trials 2017;18:503.  Back to cited text no. 46
    
47.
Ivmmeta. Ivermectin is Effective for COVID-19: Real-time Meta-analysis of 37 Studies. Available from: https://ivmmeta.com/. [Last accessed on 2020 Feb 07].  Back to cited text no. 47
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]

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