| REVIEW ARTICLE |
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| Year : 2021 | Volume
: 53
| Issue : 5 | Page : 403-411 |
Demystifying therapeutic potential of medicinal plants against chikungunya virus
Sukender Kumar1, Chanchal Garg1, Samander Kaushik2, Harpal Singh Buttar3, Munish Garg1
1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India
2 Center for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, India
3 Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada
Correspondence Address:
Prof. Munish Garg
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak - 124 001, Haryana
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijp.IJP_81_20
Viral infections are posing a great threat to humanity for the last few years. Among these, Chikungunya which is a mosquito-borne viral infection has produced enormous epidemics around the world after been rebounded. Although this infection shows a low mortality rate, patients suffer from fever, arthralgia, and maculopapular rashes, which reduce the quality of life for several weeks to years. The currently available treatments only provide symptomatic relief based on analgesics, antipyretics, and anti-inflammatory drugs which are nonspecific without satisfactory results. Medicinal plants are a widely accepted source of new molecules for the treatment of infectious diseases including viral infections. The scientific reports, primarily focusing on the anti-chikungunya activity of plant extracts, natural origin pure compounds, and their synthetic analog published from 2011 to 2021, were selected from PubMed, Google Scholar, and Scopus by using related keywords like anti-chikungunya plants, natural antivirals for Chikungunya. The present review decodes scientific reports on medicinal plants against chikungunya virus (CHIKV) infection and demystifies the potential phytoconstituents which reveals that the screening of flavonoids containing plants and phytochemicals showing efficacy against other arbovirus infections, may prove as a potential lead for drug development against CHIKV. The present article also outlines pathogenesis, clinical aspects, molecular virology, and diagnostic approaches of CHIKV infection.
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