| SHORT COMMUNICATION
|Year : 2018 | Volume
| Issue : 2 | Page : 84-87
Potentiation of pentylenetetrazole-induced neuronal damage by dimethyl sulfoxide in chemical kindling model in rats
Puja Kumari, Neha Singh, Lekha Saha
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
OBJECTIVES: Dimethyl sulfoxide (DMSO) is commonly used as a vehicle for many hydrophobic drugs. This study aimed at evaluating the effect of low dose of DMSO (0.1%) on Pentylenetetrazole(PTZ) induced neuronal damage in rats.
MATERIALS AND METHODS: Young male Wistar rats (n = 32) were divided into four groups as follows: saline control group, DMSO control group, PTZ group (35 mg/kg), and combination group (DMSO + PTZ). Animals were observed for seizure score, latency to develop kindling, percentage of animals kindled, and histopathological score of hippocampus.
RESULTS: There was a significant increase in the seizure scores and histopathological scores in the combination group as compared to PTZ-treated group. The latency to develop kindling was, however, decreased in the combination group (4th week) as compared to PTZ (6th week) group.
CONCLUSIONS: The present study has concluded that 0.1% DMSO in PTZ-induced rat model of epileptogenesis needs further optimization and should be used cautiously
Dr. Lekha Saha
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Room No. 4014, 4th Floor, Research Block B, Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
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