IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1740 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2173    
    Printed58    
    Emailed0    
    PDF Downloaded103    
    Comments [Add]    

Recommend this journal

 

 DRUG WATCH
Year : 2017  |  Volume : 49  |  Issue : 6  |  Page : 470-471

Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis


1 Department of Dermatology, 6th Military Support Unit, Ustka, Poland
2 Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, Croatia
3 Department of Cardiovascular Diseases, University Hospital “Sveti Duh,” Zagreb, Croatia
4 Department of Dermatology, Nicolina Medical Centre, Apollonia University, “P.Poni” Research Institute of Macromolecular Chemistry, Lasi, Romania

Correspondence Address:
Sandra Jerkovic Gulin
Department of Dermatology and Venereology, General Hospital Sibenik, Croatia, Stjepana Radica 83, 22000, Sibenik
Croatia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_838_16

Rights and Permissions

We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow