|LETTER TO THE EDITOR
|Year : 2015 | Volume
| Issue : 3 | Page : 341-342
Is chemo-preventive effect of Apium leptophyllum (Pers.) caused only by anti-oxidative property of flavonoids?
Department of Cell Biology and Genetics, Palacky University, Olomouc, Czech Republic
|Date of Web Publication||18-May-2015|
Department of Cell Biology and Genetics, Palacky University, Olomouc
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sedlacek J. Is chemo-preventive effect of Apium leptophyllum (Pers.) caused only by anti-oxidative property of flavonoids?. Indian J Pharmacol 2015;47:341-2
|How to cite this URL:|
Sedlacek J. Is chemo-preventive effect of Apium leptophyllum (Pers.) caused only by anti-oxidative property of flavonoids?. Indian J Pharmacol [serial online] 2015 [cited 2021 May 14];47:341-2. Available from: https://www.ijp-online.com/text.asp?2015/47/3/341/157142
I read with great enthusiasm the article by of Sahoo et al.  entitled "Chemo-preventive potential of Apium leptophyllum against DMBA induced skin carcinogenesis model by modulatory influence on." In the study, flavonoids of Marsh Parsley showed a strong protective effect against induced carcinogenesis. Due to the advances of molecular sciences, in isolation and structure elucidation techniques of various natural products, it will be interesting to determine specific bioactive compounds obtained from the flavonoid fraction of this plant. However, it is not clear, what is the real molecular basis for the observed protective effect, and which bioactive compounds produced this effect. Currently, several different molecular targets of flavonoids are discussed.  Medicinal chemists and pharmacologists have studied mainly the anti-oxidative properties of flavonoids, and their metabolites, but flavonoids may exert effects in cells through the influence of anti-apoptotic and pro-proliferative signaling pathways. During DMBA-induced carcinogenesis, protective effect can also be caused by suppression of kinase signaling cascades such as mitogen-activated protein kinases/extracellular signal-regulated kinase, phosphoinositide 3-kinase/Akt, or inhibit induced activation of epidermal growth factor receptor-related pathway [Figure 1]. ,, It can be a critical step in this carcinogenicity. However, these proliferative cascades are activated by DMBA irritation, and thus prevention of their activation by flavonoids might play an additive role in suppression of induced carcinogenesis. ,
|Figure 1: The simplified proposal of alternative action of flavonoids through suppression of pro-proliferative and anti-apoptotic kinase signaling cascades in early phase of induced carcinogenesis|
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Blocking of these pathways leads to a reduction of expression of some proliferative and anti-apoptotic factors and has been shown that these signaling pathways have a key role in the early phases of carcinogenesis.  Consequently, compounds from the flavonoid fraction of A. leptophyllum should be isolated, structurally characterized, and screened for their bioactivity in cell cultures and murine models. Whether, a part of the chemo-protective effect is not caused by the suppression of kinases related signaling pathway responsible for the cell growth and survival should be evaluated.
| » Acknowledgments|| |
This work was supported by the Czech Science Foundation (GACR 303/12/G163).
| » References|| |
Sahoo HB, Santani DD, Sagar R. Chemopreventive potential of Apium leptophyllum
(Pers.) against DMBA induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers in Swiss mice. Indian J Pharmacol 2014;46:531-7.
Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: Antioxidants or signalling molecules? Free Radic Biol Med 2004;36:838-49.
Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, et al.
Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 1997;53:1649-57.
Seelinger G, Merfort I, Wölfle U, Schempp CM. Anti-carcinogenic effects of the flavonoid luteolin. Molecules 2008;13:2628-51.
Steelman LS, Chappell WH, Abrams SL, Kempf RC, Long J, Laidler P, et al.
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) 2011;3:192-222.
Kern F, Doma E, Rupp C, Niault T, Baccarini M. Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis. Oncogene 2013;32:2483-92.