| SHORT COMMUNICATION
|Year : 2015 | Volume
| Issue : 2 | Page : 215-218
Gamma activity model for treatment-resistant bipolar psychotic mania
Shashi Ranjan Kumar, Vinod Kumar Sinha, Sai Krishna Tikka, Nishant Goyal
Department of? Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India
Objectives: The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
Methods: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power.
Results: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
Conclusions: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
Sai Krishna Tikka
Department of? Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand
Source of Support: None, Conflict of Interest: None
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