| RESEARCH ARTICLE
|Year : 2015 | Volume
| Issue : 1 | Page : 59-64
Evaluation of anti-osteoarthritic activity of Vigna mungo in papain induced osteoarthritis model
Dhaval V Patel1, Mrunal Ghag Sawant2, Ginpreet Kaur1
1 Department of Pharmacology, SPP School of Pharmacy and Technology Management, Vile Parle (West), India
2 Department of Toxicology, Haffkine Institute, Mumbai, Maharashtra, India
Aim: This study was carried out to evaluate the effect of Vigna mungo hydroalcoholic extract (VMHA) by papain induced osteoarthritis (OA) in the rat model.
Materials and Methods: OA was induced by intra-articular injection of papain (4% w/v) along with cysteine (0.03 M) on day 1, 4 and 7 in rats and VMHA was administered orally in three doses (100, 200 and 400 mg/kg) after last papain injection. The anti-osteoarthritic activity was evaluated by measuring knee joint diameter, grip strength, locomotion activity and hanging time. Histopathological analysis and acute toxicity study were also performed.
Results: VMHA improved inflammatory condition with all the doses, but significant (P < 0.05) attenuation of inflammation was present only with 400 mg/kg dose. The grip strength, locomotion activity and hanging time were also significantly (P < 0.05) improved at dose level of 100 mg/kg however other two doses (200 mg/kg and 400 mg/kg) were not found to be effective. VMHA did not show any mortality or any toxic clinical signs after oral administration of 2 g/kg dose.
Conclusion: VMHA improved arthritic condition by significantly reducing pain and inflammation.
Dr. Ginpreet Kaur
Department of Pharmacology, SPP School of Pharmacy and Technology Management, Vile Parle (West)
Source of Support: Sanctuary for Research and Development
(SA-FORD)., Conflict of Interest: None
[FULL TEXT] [PDF]*