| SHORT COMMUNICATION
|Year : 2014 | Volume
| Issue : 4 | Page : 430-432
Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
Ivan S Ivanov1, Anastasia V Sidehmenova1, Vera I Smol'yakova1, Galina A Chernysheva1, Mark B Plotnikov2
1 E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia
2 E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences; Tomsk State University, Tomsk, Russia
Objectives: To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ).
Materials and Methods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 Χ 10 -5 Μ.
Results: α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times.
Conclusion: Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.
Mark B Plotnikov
E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences; Tomsk State University, Tomsk
Source of Support: None, Conflict of Interest: None
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