| RESEARCH ARTICLE
|Year : 2014 | Volume
| Issue : 1 | Page : 100-104
Anti-anxiety effect of a novel 5-HT 3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide (6k) using battery tests for anxiety in mice
Yeshwant Vijay Kurhe, Mahesh Radhakrishnan, Devadoss Thangaraj, Deepali Gupta
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India
Objective: To investigate the anti-anxiety activity of "6k", a novel 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonist in in mice.
Materials and Methods: Anti-anxiety activity of "6k" (1, 2, and 4 mg/kg, intraperitoneally (i.p.)) was evaluated in mice by behavioral tests such as elevated plus maze (EPM), open field test (OFT), light-dark box (L&D), and hole board test (HBT). Diazepam (2 mg/kg, i.p.) served as reference standard.
Results: "6k" significantly (P < 0.05) increased the time and entries in open arm in EPM as compared to vehicle control group. Further, "6k" significantly (P < 0.05) increased the central and peripheral ambulation along with rearings and time in central area; whereas, reduced the fecal pellets in OFT as compared to vehicle control group. There was significant (P < 0.05) reduction in the latency to enter dark chamber; whereas, increased number of crossings and time in light chamber in L&D aversion test by treatment with "6k" as compared to vehicle control group. In HBT, "6k" significantly (P < 0.05) increased the number of head dipping and squares crossed; whereas, reduced the latency for first head dip and number of fecal pellets as compared to vehicle control group.
Conclusion: A novel 5-HT 3 receptor antagonist has anti-anxiety action.
Yeshwant Vijay Kurhe
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan
Source of Support: None, Conflict of Interest: None
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