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Year : 2013  |  Volume : 45  |  Issue : 4  |  Page : 403-404

Terlipressin-induced hyponatremic seizure in a child

Department of Pediatrics, Lokmanya Tilak Municipal General Hospital, Sion, Mumbai, India

Correspondence Address:
Syed Ahmed Zaki
Department of Pediatrics, Lokmanya Tilak Municipal General Hospital, Sion, Mumbai
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.114995

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Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We describe a 7-year-old male child who developed hyponatremia induced by infusion of terlipressin which resulted in a generalized seizure. After withdrawal of terlipressin, the serum sodium level became normal. Through this case, we emphasize the importance of monitoring patient's electrolyte levels during the course of terlipressin therapy.


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