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 RESEARCH ARTICLE
Year : 2013  |  Volume : 45  |  Issue : 4  |  Page : 344-347

Effect of methylprednisolone on bone mineral density in rats with ovariectomy-induced bone loss and suppressed endogenous adrenaline levels by metyrosine


1 Department of Obstetrics and Gynecology, Ataturk University, Faculty of Medicine, Erzurum, Turkey
2 Department of Obstetrics and Gynecology, Nenehatun Obstetrics and Gynecology Hospital, Ministry of Health, Erzurum, Turkey
3 Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey
4 Department of Physical Medicine and Rehabilitation, Ataturk University, Faculty of Medicine, Erzurum, Turkey
5 Department of Nuclear Medicine, Ataturk University, Faculty of Medicine, Erzurum, Turkey
6 Department of Biochemistry, Ataturk University, Faculty of Medicine, Erzurum, Turkey
7 Department of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey

Correspondence Address:
Mehmet Yilmaz
Department of Obstetrics and Gynecology, Ataturk University, Faculty of Medicine, Erzurum
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.115008

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Objectives: In this study, effect of methylprednisolone on bone mineral density (BMD) was investigated in rats with overiectomy induced bone lose and suppressed endogenous adrenalin levels, and compared to alendronate. Materials and Methods: Severity of bone loss in the examined material (femur bones) was evaluated by BMD measurement. Results: The group with the highest BMD value was metyrosinemetyrosine + methylprednisolone combination (0.151 g/cm 2 ), while that with the lowest BMD was methylprednisolone (0.123 g/cm 2 ). Alendronate was effective only when used alone in ovariectomized rats (0.144 g/cm 2 ), but not when used in combination with methylprednisolone (0.124 g/cm 2 ). In the ovariectomized rat group which received only metyrosine, BMD value was statistically indifferent from ovariectomized control group. Conclusions: Methylprednisolone protected bone loss in rats with suppressed adrenaline levels because of metyrosinemetyrosine.






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