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|Year : 2013 | Volume
| Issue : 3 | Page : 316-319
Organising Secretary IPSCON 2012
|Date of Web Publication||15-May-2013|
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Chopde C T. Errata. Indian J Pharmacol 2013;45:316-9
The below Abstracts [MIS - 73, MIS - 74, IND - 13, RDU - 28, RDU - 29, RDU - 30, RDU - 31, NEU - 61, NEU - 62, GIT - 22, GU-6] are inadvertently missed out in "Indian Journal of Pharmacology / December 2012 /
Vol 44 / Supplement"
MIS - 73
Study of Cutaneous Adverse Drug Reactions in a Tertiary Care Hospital
Mohammed Yunus Khan*, Prudwidhar, Venkata Srinivas, Arun Jyothi, Parushuram, Murali
Kakatiya Medical College, Warangal, Andhra Pradesh
Objectives: To evaluate various patterns of cutaneous adverse drug reactions. Materials and Methods: All cases suspected of having a CADR during the period of one and half year were evaluated by a prospective study. The causal relationship with the offending drug was established as per WHO-UMC causal assessment scale. Only certain, probable and possible cases were considered for the study and the data was subjected to descriptive and statistical analysis. Results: The clinical spectrum of CADRs ranged from the more common mild to moderate reactions to less frequent serious reactions like SJS / TEN. Most common presenting complaint was skin rash (44.2%). Erythematous drug eruption (30.7%) and fixed drug eruption (19.2%) were most common clinical pattern of reaction. Antimicrobials (44.2%) and Analgesics/NSAID'S (28.5%) were most common causative drug category. According to Hartwig severity scale most of the reactions were of moderate type (65.6%).According to WHO-UMC criteria most of the reactions were probable (53.5%) followed by possible (42.1%). Based on Schumock Thornton criteria majority of CADR'S were not preventable (79.2%). Majority of CADR'S were associated with history of allergy/past reactions (70.7%). Most common laboratory abnormality associated with CADR was increased AEC (28.5%). Majority of CADR'S were treated by withdrawal and by giving antihistaminics/corticosteroids and switching to different therapy (56.3%). Majotity of CADR'S resolved without any sequelae (53.5%) Conclusion: This study shows that a wide range CADR'S from mild to moderate to severe like SJS/TEN are possible. Similar studies conducted over longer period are necessary to validate the findings. Adverse drug reaction monitoring should be a ongoing and continous process because newer and newer drug molecules are being introduced in the market and monitoring of adverse effect of new drug molecules particularly serious adverse effects is the need of the hour. Physicians and other health care professionals should be made aware of and trained in rational drug use and drug monitoring process.
MIS - 74
Pharmacological Evaluation of Honey and Shatdhdhaut Ghrut on Burn Wound Healing Activity in Rats
Swati A. Moholkar*, P. S. Worlikar, S. V. Bhalerao
Department of Pharmacology, Dr. D. Y. Patil Medical College,
D.Y. Patil University, Pimpri, Pune
Objective: The objective of present investigation was to evaluate the effect of Honey (H), Shatdhadhaut ghrut (SDG) in burn wound model in rats. Materials and Methods: Sprague Dawley rats used for burn wound model. The partial thickness burn wounds were inflicted upon the rats under ketamine anesthesia by pouring hot boiling water in a sealed metal cap on the shaven back of the rats. The animals divided into 5 groups of 6 animals each. Untreated rats used as control. 1 ml of povidone iodine (PI) used as active control, Honey (1ml), SDG (1ml) alone and combination of H + SDG (1ml) used for this study. Study treatments applied locally. The treatment was initiated on day 0 and continued for 21 days. The parameters measured in this study % wound closure, Period of re-epithelization & wound surface area. The observations made on days 0,4,8,12,16 & 21 days. Result: In the present study the results compared with untreated control. The present study showed that H + SDG, Honey, SDG promoted wound healing activity as compared to untreated control (P<0.001). H + SDG, H, SDG showed better wound healing activity as compared to PI, an active control. Conclusion: The order of wound healing activity was H + SDG > H > SDG > PI > UC.
IND - 13
Anti-Inflammatory Activity of Curcuminoid and Oil Free Curcuma Longa Extract: A Comparative Evaluation with Curcuminoids and Turmerones
Ashish Subhash Bagad, Joseph Joshua Allan, Natarajan Bhaskaran, Amit Agarwal
R&D centre, Natural Remedies, Bangalore, India
Objective: Curcuma longa (C. longa) has been extensively used in the treatment of inflammatory conditions and the anti-inflammatory potential has been attributed to curcuminoids and turmerones components of the rhizome. The present study evaluated the anti-inflammatory activity of curcuminoids and oil free aqueous extract (COFAE) of C. longa and compared with that of curcuminoids and turmerones, the bioactive components of C. longa well reported in the published literature for the anti- inflammatory potential. Materials and Methods: The acute and chronic anti-inflammatory potential was investigated using the xylene induced mouse ear edema and cotton pellet-induced granuloma methods respectively. Dexamethasone and Diclofenac were used as positive controls. COFAE, curcuminoids and turmerones anti-inflammatory activity was evaluated at three dose levels each in both the anti-inflammatory models. Results: The COFAE of C. longa at three dose levels significantly (p ≤ 0.05) inhibited inflammation in acute and chronic models of inflammation, as evidenced by reduction in ear weight and decrease in wet as well as dry weights of cotton pellets, when compared to the vehicle control. COFAE at low dose revealed better activity in the inflammatory models and the effect was even comparable to curcuminoids and tumerones, the proven bioactive components of C. longa. Conclusion: Curcuminoids and oil free aqueous extract of C. longa revealed significant anti-inflammatory effect and was found to be comparable to curcuminoids and turmerones.
RDU - 28
Parents' Knowledge, Attitude and Perception about the Commonly Used Drugs and their Adverse Drug Reactions in Children
Dawane J.S., Borole K.D ,Pandit V.A., Salunkhe S.D.
Bharati Vidyapeeth Deemed University Medical College,
Objectives: To assess parents' knowledge about commonly used drugs in children for minor ailments and their adverse drug reactions (ADRs). To determine factors affecting knowledge, attitude and perception of parents about these drugs. Materials and Methods: A prospective cross sectional study was carried out in Pune during February-September 2012. 200 Parents of the children below 12 yrs of low socioeconomic group were included in the study. Out of both the parents, we interviewed one who was mainly involved in taking care of their child. A standardized, structured and validated questionnaire which covered socio-demographic, occupational, educational characteristic of parents and their knowledge about drugs and ADRs was used for this purpose. Questionnaires translated into local language (Marathi). Four volunteers were trained to fill up the questionnaire. After obtaining consent, parents were interviewed and information was filled in questionnaires. Results: Out of the total 200 parents, 94 % caretakers were mothers. It was observed that 74 % respondents had no knowledge about medicines given to their children and 86.5% unaware about ADRs. Most of the irregularities were observed in measuring dose, increasing duration, confusion in multiple drugs and storage of medicines. Low literacy has a major impact on patients' ability to understand potential adverse reactions and instructions on correct dosing of medications. Conclusion: Study showed that parents have inadequate knowledge and misconceptions about drug use and ADRs. Identifying weak areas in parents' management to their children's ailments are essential. Appropriateness of written medical information in vernacular language can improve parents' perceptions of drug warnings.
RDU - 29
Knowledge, Attitude and Practice of Pharmacovigilance among Doctors in a Tertiary Care Teaching Hospital
Sanghavi D.R., Dhande P. P., Pandit V.A.
Department of Pharmacology, Bharati Vidyapeeth Deemed University Medical College, Pune- 411043. India.
Objectives: Toevaluate knowledge, attitude and practice of spontaneous ADR reporting amongdoctors in a tertiary care teaching hospital in Pune. Materials and Methods: Cross sectional study conducted in Nov 2011 at a tertiary care teaching hospital in Pune.300 participants were explained purpose of the study and asked to fill in a questionnaire containing 17 questions -7 about knowledge, 6 about attitude and 4 about practice of pharmacovigilance. Results: Among the 300 participants, 100 were consultants and 200 were post graduate students. 96% agreed ADRs should be reported by clinicians but majority were unaware of the methodology of reporting. Major reasons for under-reporting were:-not knowing where to report, time consuming & not fitting in their busy schedule, could not decide whether ADR is worth reporting. 76 % participants experienced several ADRs in patients during their practice but only reported them verbally to their department heads or unit heads.92% of the respondents were willing to practice pharmacovigilance if they are trained. Conclusion: Doctors working in the study setup have a positive attitude for ADR reporting but lacked adequate knowledge of ADR reporting system. So they could not practise pharmacovigilance. Present study highlights the importance of education and training for improving ADR reporting.
RDU - 30
Drug Utilization Study of Anti-Hypertensive in Obstetric and Gynaecology Department in Tertiary Care Hospital
Sharan Kumar K B*, Laxman Reddy Nadithe, B Rameshchandra, Pushpalatha Chinnnam, Mohammed Mohsin.
Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar
Objectives: To evaluate the drug utilization of antihypertensive in obstetric & gynaecology department in tertiary care hospital in karimnagar city. Materials and Methods: A retrospective study of one year duration was undertaken during December-November 2012. WHO basic drug indicators were used for studying the prescribing trends. Results: A total of 200 prescriptions were studied & the average number of drugs per prescription was 2.33%. 8.45% of generics & 86.40% of essential drugs were prescribed. 91.55% were non generic names used. 8% were irrational prescription. The frequency of use of Methyldopa was highest followed by Nifedepine, Labetolol, Furosemide & Amlodepine etc. The use of the safest drug, Methyl dopa was among 75% of the patients. Conclussion: The incidence of polypharmacy was high. Irrational prescriptions were few. The data presented here will be useful in future, long term and more extensive drug utilization studies in hospital and in promotion of rational prescribing & drug use in hospital.
RDU - 31
Impact of Monitoring and Training on the Process of Drug Administration as suggested by Medical Council of India
Garima Bansal*, Prem Prakash Khosla, Surabhi Gupta
Department of Pharmacology, Subharti Medical College and Hospital, Meerut (U.P.)
Objective: To study impact of monitoring and training on the process of drug administration as a part of pharmacovigilance process as suggested by Medical Council of India. Materials and Methods: This study was conducted in Subharti Medical College and Hospital, Meerut. Checklists were made for oral and parenteral drug administration on the basis of Black Book (Feb. 2009) & NMC guide (2006).It included: checking order, expiry date, verbal/non verbal response, asepsis, needle size, separate needles for aspiration and injections, removing air, quick thrust, changing and regulating insertion site, method of pouring tablets and liquid medicine, clean and replace instrument after medication, documentation, observing for complications. Training was given in the form of group discussion, demonstration and by providing checklists. Monitoring of nursing staff while administering drugs was done before and after the training programme. Observation: Drug administration was monitored in 312(parenteral) & 120(oral) cases. Training of nurses and monitoring improved drug administration process: oral (46%) and parenteral (43%). There was remarkable improvement in hand washing prior (55.8%) and post drug administration (59.9%); observing patient responses prior to parenteral drug administration (63.6%); correct time (64.2%), correct method of pouring tablets (67.5%) and liquid (53.3%) medicine; regulating iv after every 15-20 minutes and observing for potential complications after drug administration (50%). Conclusion: This study suggests that the correct drug administration process could be improved by implementing management of medication and pharmacovigilance programme of MCI .There is need to sensitize on importance of correct process of drug administration by nurses.
NEU - 61
Antidepressant Activity of Methanolic Extract of Acorus calamus Leaves in Albino Mice
Padmaja Shetty K*, Pushpa V H, Suresha R N, Vaibhavi P S, Pragathi B, Vinod G T
JSS Medical College, Mysore
Objective: The aim of this study was to evaluate the antidepressant activity of the methanolic extract of Acorus calamus leaves in albino mice. Materials and Methods: Swiss albino mice weighing around 25 - 30g of either sex were randomly selected and divided into 4 groups (n = 6): Control (vehicle), Standard (15mg/kg of imipramine), T1 (100mg/kg of extract ), T2 (50mg/kg of extract + 7.5mg/kg of imipramine). Study was conducted for 14 days. Animals were administered drug orally everyday morning for 14 days. Experiments were carried out on the 14th day and on the day of experiment each mouse was fed orally with respective drug 1 hr prior to conducting the test. The anti- depressant activity was studied using forced swim test (FST) and tail suspension test (TST). Results: Methanolic extract of Acorus calamus leaves produced significant antidepressant effect as shown by reduction in immobility time in both tail suspension and forced swim test as compared to control. The efficacy of combination of extract (50mg/kg) and standard imipramine (7.5mg/kg) was comparable with that of standard imipramine (15mg/kg). The extract at a dose of 100mg/kg showed significantly less antidepressant activity compared to imipramine. Conclusion: The methanolic extract of Acorus calamus leaves shows significant antidepressant activity. Hence they can be used as potential adjuvants with the conventional antidepressant drugs for treatment of depression.
NEU - 62
Neuroprotective effect of Chrysin in spinal cord injury via inhibition of endogenous enzymes
V. Shivakumar*, Amit D. Kandhare, Mohammad Adil, Anuchandra R. Rajmane, Pinaki Ghosh, Subhash L. Bodhankar
Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Paud Road, Pune-411 038, India
Objective: The aim of present investigation was to evaluate neuroprotective efficacy of Chrysin in experimental spinal cord injury (SCI) model in rats. Methods: SCI was induced in male Sprague-Dawley rats by placing an aneurysm clip extradurally for 60 s at T 10 . Rats received treatment with either vehicle (SCI control) or Chrysin (10, 20 and 40 mg/kg, p.o.) for 28 days. The various behavioral (allodynia and hyperalgesia), biochemical and molecular parameters were determined in the spinal cord. The histopathological evaluation of spinal cord, testis, kidney and urinary bladder were carried out. Results: Chronic treatment with Chrysin (20 and 40 mg/kg) significantly and dose dependently (P <0.01 and P <0.001, respectively) attenuated the decrease in urine output, foot print length, stride width, BBB score, sperm count and motility as well as weight of various organs (testis, seminal vesicle, prostate gland and urinary bladder). It significantly improved (P <0.01 and P <0.001, respectively) the nociceptive threshold, locomotor behavior, MNCV and SNCV. The decreased levels of SOD and GSH were significantly restored by the treatment of Chrysin (20 and 40 mg/kg). SCI resulted in significant increase (P < 0.01 and P < 0.001, respectively) in the levels of MDA, MPO, NO as well as TNF-α, IL-1β, Bax, Bcl-2 and Caspase-3 which were significantly attenuated by the treatment of Chrysin. Histological aberration induced after SCI in spinal cord, testis, kidney and urinary bladder were restored by the treatment of Chrysin. Conclusion: Chrysin is a potential flavone bearing antioxidant, antiapoptotic and disease modifying property acting via modulation of endogenous biomarker, decreased in DNA damage to inhibit SCI induced neuropathic pain.
GIT - 22
Elucidation of biomarkers involved in eradication of H. pylori by quercetin in animal model of gastritis: A peep into molecular perturbations
Anuchandra Rajmane*, V. Shiva Kumar, Mohammad Adil, Amit D. Kandhare, Pinaki Ghosh, Subhash L. Bodhankar
Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Paud Road, Pune-411 038, India
Objective: To study the therapeutic effect of quercetin in amelioration of gastritis infected with H. pylori by assessing expression of various cellular biomarkers. Material and methods: Gastritis was induced in male wistar rats by administration of sodium taurocholate, ammonia and low dose indomethacin (1 mg/kg p.o.) for 2 months. Then they were infected with H. pylori broth. Animals were divided into 7 treatment groups. Group1 received vehicle (1% sodium CMC), Group 2, 3 and 4 received 10, 20 and 40 mg/kg quercetin/day, Group 5 received CAO (Clarithromycin 15 mg/kg, Amoxycillin 20 mg/kg, Omeprazole 10 mg/kg)/day, Group 6 received (Quercetin 40 mg/kg + CAO) and group 7 was non ulcerated and non infected. After 4 weeks of treatment, animals were sacrificed and gastric tissue dissected out for biochemistry assessment. Results: H. pylori specific non virulant and virulant genes were not detected in the animals treated with CAO and quercetin 20 and 40 mg/kg. RT-PCR revealed significant (P < 0.01) up regulated expression of mtDNA ATPase subunits 6 and 8 mRNA, CGRP, ITF, survivin, bcl2, and down regulated expression of caspase-3, bax and MCP-1 at 20 and 40 mg/kg dose of quercetin. Flow cytometric analysis revealed significant dose dependent anti apoptotic and ROS lowering effect of quercetin (P < 0.001). ELISA revealed dose dependent inhibition of TNF-α and IL-1β (P < 0.001). Quercetin and CAO did not show a synergistic activity. Conclusion: Mechanism of anti H. pylori activity of quercetin may be mediated by confluence regulation of various biomarkers in gastric mucosa.
Effect of Type-A Procyanidine Polyphenols from Bark of Cinnamomum Zeylanicum on Allergic Rhinitis Model in Balb-C Mice
Amit D. Khandare 1 , Urmila M. Aswar 2 , V. Mohan 3 , Subhash L. Bodhankar 1 , Prasad A. Thakurdesai 3
1 Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Paud Road, Pune-411 038, India., 2 Department of Pharmacology, Sinhgad Institute of Pharmacy, Narhe, Pune-411041., 3 Indus Biotech Private Limited, 1- Rahul Residency, Off SalunkeVihar Road, Kondhwa, Pune 411 048, India.
Objective: To evaluate the effect of intranasal administration of Type-A procyanidine polyphenols (TAPP) isolated from Cinnamomum zeylanicum bark in OVA induced experimental allergic rhinitis in Balb-C mice. Methods: Separation and characterization (HPLC) of TAPP from Cinnamomum zeylanicum bark was carried out. Male BALB/c mice (18-22 g) were sensitized with injection of 500 μl sensitization solution consist of 50 mg of OVA, 1 g of aluminium hydroxide and 0.5 ml of 1×1010 Bordetella bronchiseptica on alternate days till day 13. Mice received intranasal treatment of either saline (AR control) or TAPP (3, 10 and 30 μg/kg/nostril) from day 14 to day 21. On day 21, mice were challenged with OVA (5 μl per nostril of 5% solution). The behavioral (nasal rubbing and sneezing), biochemical (serum IgE, nitrite and histamine levels) and histopathological (nasal mucosa, lungs and spleen) assessments were performed. Results: Characterization data (HPLC fingerprinting) showed the presence of pentameric procyanidin flavonoid in TAPP (purity- 75.9%). Treatment with TAPP (10 and 30 μg/kg/nostril) showed significant and dose dependant attenuation (P <0.01 and P <0.001, respectively) in the number of nasal rubbing, sneezing, spleen weight, lung weight, serum IgE and histamine AR control mice. TAPP failed to produce any effect on serum nitrite. Histopathological aberrations in nasal mucosa, lung and spleen induced by the ovalbumin were attenuated by the treatment of TAPP (10 and 30 μg/kg/nostril). Conclusions: TAPP showed efficacy in alleviating symptoms of animal model of OVA induced allergic rhinitis through down regulation of IgE and histamine release.
The error is regretted
Prof. C. T. Chopde,
Organising Secretary IPSCON 2012