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Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 387-389

Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats


Department of Pharmacology, L.T.M. Medical College, and L.T.M.G. Hospital, Sion, Mumbai, India

Correspondence Address:
Amol N Patil
Department of Pharmacology, L.T.M. Medical College, and L.T.M.G. Hospital, Sion, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.96344

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Aims: To study anti-ulcer effect of Amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation-induced gastric ulcers in wistar rats. Materials and Methods: Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed 't ' test. P<0.05 was considered statistically significant. Results: Amlodipine produced significant (P<0.05) decrease in ulcer index and gastric pH as compared to control. It also produced significant (P<0.05) increase in gastric volume as compared to ranitidine. The anti-ulcer effects of ranitidine were significantly higher than that of amlodipine. Combination of amlodipine and ranitidine did not show significant increase in anti-ulcer activity as compared with ranitidine alone. Conclusions: Amlodipine produced significant anti-ulcer effects in all 3 experimental models. Amlodipine increased the volume of gastric secretions as compared to ranitidine.






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