| RESEARCH ARTICLE
|Year : 2012 | Volume
| Issue : 1 | Page : 63-67
Anxiolytic activity of methanol leaf extract of Achyranthes aspera Linn in mice using experimental models of anxiety
Chandana C Barua1, Archana Talukdar1, Shameem Ara Begum1, Prabodh Borah2, Mangala Lahkar3
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India
2 Department of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, India
3 Department of Pharmacology, Gauhati Medical College, Guwahati, Assam, India
Objective: To study the anxiolytic activity of methanol extract of Achyranthes aspera Linn (Amaranthaceae).
Materials and Methods: Male Swiss albino mice were used. Methanolic extract of Achyranthes aspera (MEAA) was administered in the doses of 100, 300 and 600 mg/kg p.o. Hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration (LDE) tests were used for determination of anxiolytic activity.
Results: The methanolic extract of Achyranthes aspera significantly increased the number and duration of head poking in HB test. The extract also significantly increased the time spent and the number of entries in open arm in EPM. In LDE test, the extract produced significant increase in time spent and number of crossings and decreased the duration of immobility in light box. In OFT, the extract showed significant increase in number of rearing, assisted rearing and the squares crossed.
Conclusion: In the present study, MEAA exhibited anxiolytic activity which might be attributed to its phyto-constituents viz. alkaloid, steroid and triterpenes. Since Achyranthes aspera is ubiquitous and abundantly grown, it could be a fairly economical therapeutic agent for management of anxiety disorders.
Chandana C Barua
Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati
Source of Support: None, Conflict of Interest: None
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