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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 718-721

Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat

1 Department of Pharmacology, Nootan Pharmacy College, Visnagar- Gujarat, India
2 Department of Pharmaceutics, Nootan Pharmacy College, Visnagar- Gujarat, India

Correspondence Address:
Aaishwarya B Deshmukh
Department of Pharmacology, Nootan Pharmacy College, Visnagar- Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.89834

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Objective : To assess the renoprotective activity of the water extract of Annona squamosa in 5/6 nephrectomized animals. Materials and Methods : For evaluating the renoprotective effects of Annona squamosa, 5/6 nephrectomized rats were used as a model for renal failure. The effects of hot-water extract of leaves of Annona squamosa L. (A. squamosa) at a dose 300 mg/kg bw on biochemical and urinary parameters like plasma urea, plasma creatinine, and urine creatinine were analyzed. For elucidating its effect on oxidative stress, renal superoxide dismutase (SOD) levels were measured. Results : Nephrectomized rats (5/6) showed a significant rise in plasma urea and creatinine levels with a stable fall in urine creatinine. Treatment with A. squamosa extract (300 mg/kg bw) lead to a significant fall in the plasma urea and creatinine values with partial restoration to normal values along with a significant rise in the activity of SOD. Conclusion : Thus, therapeutic strategies against oxidative stress could be effective in renal diseases. This study provides an indication to investigate further the efficacy of A. squamosa as a novel agent for alleviating renal failure.


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