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 SHORT COMMUNICATION
Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 714-717

Natriuretic and saluretic effects of Hemidesmus indicus R. Br. root extracts in rats


Department of Pharmacognosy and Phytochemistry, KLE University's College of Pharmacy, JNMC Campus, Nehru Nagar, Belgaum- 590 010, Karnataka, India

Correspondence Address:
Navneet B Gadge
Department of Pharmacognosy and Phytochemistry, KLE University's College of Pharmacy, JNMC Campus, Nehru Nagar, Belgaum- 590 010, Karnataka
India
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Source of Support: ICMR, New Delhi, Conflict of Interest: None


DOI: 10.4103/0253-7613.89833

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Objective : The present study was aimed to investigate the diuretic effects of aqueous (AqE) and ethanolic (EtE) crude extracts of Hemidesmus indicus R. Br. roots (family - Asclepiadaceae) using acute model in rats. Materials and Methods : A single individual dose of AqE and EtE of H. indicus root (200 mg/kg and 400 mg/kg, p.o., each), frusemide and hydrochlorothiazide, (25 mg/kg, p.o., each) as reference diuretic drugs were administered orally to dehydrated rats. Control group rats were fed with normal saline (25 ml/kg, p.o.). All rats were caged in metabolic cages in a pairs and their urine output was monitored at 5 and 24 h intervals. Results : Both extracts significantly increased the urine output in higher doses. Although, the onset of this diuretic action was gradual (within 5 h), it lasted throughout the studied period (up to 24 h). Further, the intensity of diuresis induced by AqE (400 mg/kg) in 5 h was almost similar to that of frusemide and hydrochlothiazide. AqE of H. indicus root also caused marked increase in urinary Na + and K + levels. However, the routine urinalysis showed non-significant alterations in pH and specific gravity by either dose of crude extracts of H. indicus roots. Conclusions : These effects demonstrate possible diuretic actions of H. indicus root extracts and support its folklore use in various urinary ailments. Further study need to be done to characterize active phytoconstituents.






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