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 SHORT COMMUNICATION
Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 710-713

Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice


Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

Correspondence Address:
Pooja Sinoriya
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.89832

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Objective : To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. Materials and Methods : The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice. Results : Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination. Conclusion : The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity.






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