| SHORT COMMUNICATION
|Year : 2011 | Volume
| Issue : 6 | Page : 710-713
Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice
Pooja Sinoriya, R Irchhaiya, Bhawna Sharma, Gayatri Sahu, Santosh Kumar
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
Objective : To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice.
Materials and Methods : The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice.
Results : Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination.
Conclusion : The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity.
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh
Source of Support: None, Conflict of Interest: None
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