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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 707-709

Subchronic treatment with fluoxetine attenuates the proerectile effect of Aspidosperma ulei Markgr (Apocyanaceae)

1 Northeast Network on Biotechnology, Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Brazil
2 Departments of Organic and Inorganic Chemistry, Federal University of Cearß, Fortaleza, Brazil
3 Departments of Physiology and Pharmacology, Federal University of Cearß, Fortaleza, Brazil
4 Department of Chemical Biology, Regional University of Cariri, Crato, CE, Brazil

Correspondence Address:
JosÚ Galberto Martins da Costa
Departments of Physiology and Pharmacology, Federal University of Cearß, Fortaleza
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.89831

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Objective : To evaluate the ability of acute or chronic treatment with fluoxetine to alter the proerectile effect of Aspidosperma ulei alkaloid-rich fraction (F3-5). Materials and Methods : In the first series of experiments, three groups of mice received either a single intraperitoneal injection of vehicle, F3-5 (25 mg/kg) or fluoxetine (10 mg/kg) + F3-5. Three behavioral responses were counted over a period of 30 min: erection, erection-like response and genital grooming. In a second series of experiments, animals treated for 13 days with fluoxetine or fluoxetine + F3-5 were assessed. Results : A. ulei has been suggested to have proerectile effect in mice. Subchronic (13-d) treatment with fluoxetine resulted in a reduction in the number erections in F3-5-treated mice. Conclusion : Sexual dysfunction associated with antidepressant treatment continues to be a major compliance issue for antidepressant therapy. Acute administration of fluoxetine resulted in a near total reversal of the proerectile effect of F3-5.


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