| SHORT COMMUNICATION |
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| Year : 2011 | Volume
: 43
| Issue : 6 | Page : 707-709 |
Subchronic treatment with fluoxetine attenuates the proerectile effect of Aspidosperma ulei Markgr (Apocyanaceae)
Adriana Rolim Campos1, Daniel Esdras de Andrade Uchôa2, Edilberto Silveira Rocha2, José Galberto Martins da Costa3, Vietla Satyanarayana Rao4
1 Northeast Network on Biotechnology, Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Brazil
2 Departments of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Brazil
3 Departments of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
4 Department of Chemical Biology, Regional University of Cariri, Crato, CE, Brazil
Correspondence Address:
José Galberto Martins da Costa
Departments of Physiology and Pharmacology, Federal University of Ceará, Fortaleza
Brazil
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.89831
Objective : To evaluate the ability of acute or chronic treatment with fluoxetine to alter the proerectile effect of Aspidosperma ulei alkaloid-rich fraction (F3-5).
Materials and Methods : In the first series of experiments, three groups of mice received either a single intraperitoneal injection of vehicle, F3-5 (25 mg/kg) or fluoxetine (10 mg/kg) + F3-5. Three behavioral responses were counted over a period of 30 min: erection, erection-like response and genital grooming. In a second series of experiments, animals treated for 13 days with fluoxetine or fluoxetine + F3-5 were assessed.
Results : A. ulei has been suggested to have proerectile effect in mice. Subchronic (13-d) treatment with fluoxetine resulted in a reduction in the number erections in F3-5-treated mice.
Conclusion : Sexual dysfunction associated with antidepressant treatment continues to be a major compliance issue for antidepressant therapy. Acute administration of fluoxetine resulted in a near total reversal of the proerectile effect of F3-5.
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