| SHORT COMMUNICATION
|Year : 2011 | Volume
| Issue : 6 | Page : 703-706
A comparative study of dalteparin and unfractionated heparin in patients with unstable angina pectoris
Hanmant S Amane1, NP Burte2
1 Department of Pharmacology, SDM Medical College and Hospital, Sattur, Dharwad, Karnataka, India
2 Department of Pharmacology,M.N.R. Medical College, Sangareddy, Andhra Pradesh, India
Objective : To compare the efficacy and safety profile of dalteparin, a low-molecular-weight heparin with a standard unfractionated heparin in patients with unstable angina pectoris.
Materials and Methods : This was a 6-month, prospective, parallel, randomized and open-labeled study. Patients of angina pectoris were randomized to receive either unfractionated heparin or dalteparin for 5 days. They were followed for 21 days during three visits on 1 st , 5 th and 21 st days. A series of resting electrocardiogram were undertaken in all patients on each visit.
Results : The frequency of the combined clinical outcome of death, myocardial infarction and recurrence of angina was similar during 21 days of follow-up with either dalteparin or intravenous unfractionated heparin. In patients who received dalteparin 2.43% patients developed minor bleeding in the form of epistaxis and 2.5% patients who received unfractionated heparin developed minor bleeding in the form of macroscopic hematuria.
Conclusion : Dalteparin is as effective and safe as unfractionated heparin in the treatment of unstable angina. Dalteparin does not require routine laboratory monitoring as with unfractionated heparin.
Hanmant S Amane
Department of Pharmacology, SDM Medical College and Hospital, Sattur, Dharwad, Karnataka
Source of Support: None, Conflict of Interest: None
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