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 SHORT COMMUNICATION
Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 703-706

A comparative study of dalteparin and unfractionated heparin in patients with unstable angina pectoris


1 Department of Pharmacology, SDM Medical College and Hospital, Sattur, Dharwad, Karnataka, India
2 Department of Pharmacology,M.N.R. Medical College, Sangareddy, Andhra Pradesh, India

Correspondence Address:
Hanmant S Amane
Department of Pharmacology, SDM Medical College and Hospital, Sattur, Dharwad, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.89830

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Objective : To compare the efficacy and safety profile of dalteparin, a low-molecular-weight heparin with a standard unfractionated heparin in patients with unstable angina pectoris. Materials and Methods : This was a 6-month, prospective, parallel, randomized and open-labeled study. Patients of angina pectoris were randomized to receive either unfractionated heparin or dalteparin for 5 days. They were followed for 21 days during three visits on 1 st , 5 th and 21 st days. A series of resting electrocardiogram were undertaken in all patients on each visit. Results : The frequency of the combined clinical outcome of death, myocardial infarction and recurrence of angina was similar during 21 days of follow-up with either dalteparin or intravenous unfractionated heparin. In patients who received dalteparin 2.43% patients developed minor bleeding in the form of epistaxis and 2.5% patients who received unfractionated heparin developed minor bleeding in the form of macroscopic hematuria. Conclusion : Dalteparin is as effective and safe as unfractionated heparin in the treatment of unstable angina. Dalteparin does not require routine laboratory monitoring as with unfractionated heparin.






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