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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 689-693

Antidiarrheal potential of standardized extract of Rhododendron arboreum Smith flowers in experimental animals

1 Department of Pharmacology, Goel Institute of Pharmacy & Sciences, Lucknow, India
2 Department of Pharmacology, Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (Council of Scientific and Industrial Research), Rana Pratap Marg, Lucknow, Uttar Pradesh, India
3 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinga Nagar, Ghatikia, Bhubaneswar, Orissa, India

Correspondence Address:
Neeraj Verma
Department of Pharmacology, Goel Institute of Pharmacy & Sciences, Lucknow
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Source of Support: Indian Council of Medical Research (ICMR) and Department of Science and Technology (DST), New Delhi, Conflict of Interest: None

DOI: 10.4103/0253-7613.89827

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Objective : To investigate standardized ethyl acetate fraction of Rhododendron arboreum (EFRA) flowers for antidiarrheal activity in experimental animals. Materials and Methods : A simple sensitive high performance thin layer chromatography (HPTLC) method was used for the determination of hyperin in EFRA. The standardized fraction was investigated for castor oil, magnesium sulfate-induced diarrhea, measurement of gastrointestinal transit using charcoal and castor oil-induced enteropooling. Results : The concentration of hyperin in flowers of R. arboreum was found to be 0.148% by HPTLC. Oral administration of EFRA at 100, 200 and 400 mg/kg exhibited dose-dependent and significant (P<0.05-0.001) antidiarrheal potential in castor oil and magnesium sulfate-induced diarrhea. EFRA at doses of 100, 200 and 400 mg/kg also produced significant (P<0.05-0.001) dose-dependent reduction in propulsive movement in castor oil-induced gastrointestinal transit using charcoal meal in rats. EFRA was found to possess an antienteropooling in castor oil-induced experimental animals by reducing both weight and volume of intestinal content significantly. Conclusion : These findings demonstrate that standardized ethyl acetate fraction of R. arboreum flowers has potent antidiarrheal activity thus justifying its traditional use in diarrhea and have great potential as a source for natural health products.


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