| RESEARCH ARTICLE |
|
| Year : 2011 | Volume
: 43
| Issue : 6 | Page : 662-666 |
Screening of Ficus religiosa leaves fractions for analgesic and anti-inflammatory activities
Vishal Gulecha1, T Sivakumar2, Aman Upaganlawar3, Manoj Mahajan3, Chandrashekhar Upasani3
1 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik;Department of Medicinal Chemistry, Nandha College of Pharmacy, Erode, Tamilnadu, India
2 Department of Medicinal Chemistry, Nandha College of Pharmacy, Erode, Tamilnadu, India
3 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, India
Correspondence Address:
Vishal Gulecha
Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik;Department of Medicinal Chemistry, Nandha College of Pharmacy, Erode, Tamilnadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.89822
Objective : To evaluate the different fractions of dried leaves of Ficus religiosa Linn for analgesic and anti-inflammatory activity using different models of pain and inflammation
Materials and Methods : The analgesic activity of F. religiosa carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. Five different fractions (FRI, FRII, FRIII, FRIV and FRV) of F. religiosa at the dose level of 20 and 40 mg/kg, p.o were tested.
Results : The fraction FRI (40 mg/kg, p.o.) and FRIII (40 mg/kg, p.o) were found to be more effective (P<0.01) in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation, and acetic acid induced writhing compared to the other fractions. FRI (20 mg/kg, p.o.) and FRIII (20 mg/kg, p.o.) were also found to be more effective in increasing latency period in tail flick method.
Conclusion : Out of five different fractions of F. religiosa leaves tested, FRI and FRIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.
[FULL TEXT] [PDF]*
|
