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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 648-651

Repeated administration of propofol upregulated the expression of c-Fos and cleaved-caspase-3 proteins in the developing mouse brain

1 School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu, 221002, China
2 Neurobiology, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu Province, China

Correspondence Address:
Liu Yi
School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu, 221002
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Source of Support: “Qing-Lan” Project of Jiangsu Province, China; Natural Science Foundation of Jiangsu Province (No. BK2009253); the Industrialization of Scientifi c Research Promotion Projects of Colleges and Universities in Jiangsu Province, China (NO. JHZD09-23); Natural Science Funds for Colleges and Universities in Jiangsu Province, China (NO. 09KJB350003); Jiangsu Provincial Key Laboratory of Biological Therapy for Cancer in Xuzhou Medical College (NO. JSBL0803; C0903; C0904); Natural Science Foundation for Postgraduate Invovation in School of Pharmacy, Xuzhou Medical College (2010YKYCX002), Conflict of Interest: None

DOI: 10.4103/0253-7613.89819

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Objectives and Aim : This study was designed to analyze the relationship between the expression of c-Fos protein and apoptosis in the hippocampus following propofol administration in infant mice. There are reports that certain drugs, including the general anesthetics applied in pediatrics and obstetrics, could block N-methyl-D-aspartate glutamate receptors and activate γ-aminobutyric acid type A receptors. Furthermore, some anesthetics could trigger neuroapoptosis and the expression of c-Fos in the developing rodent brain. Propofol is a general anesthetic increasingly used in pediatrics and obstetrics, and is reported to be able to interact with both γ-aminobutyric acid type A and N-methyl-D-aspartate glutamate receptors. No adequate evaluations have been available as to whether the dosage of propofol to maintain anaesthesia could trigger the expression of c-Fos and apoptosis. Materials and Methods : Intraperitoneal injections of propofol (50, 100 and 150 mg/kg) or vehicle were administered every 90 minutes (4 times) in infant mice (5-7 days old). 30 minutes after the final administration, the protein expressions of c-Fos and cleaved-caspase-3 in the hippocampus were determined by immunohistochemistry and Western blotting. Results : It was demonstrated that the expressions of cleaved-caspase-3 and c-Fos were upregulated in the hippocampal CA3 region in this study. Conclusions : The upregulated c-Fos expression induced by repeated injections of propofol might evoke neuroapoptosis.


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