| RESEARCH ARTICLE
|Year : 2011 | Volume
| Issue : 6 | Page : 644-647
Antihyperlipidemic potential of Cedrus deodara extracts in monosodium glutamate induced obesity in neonatal rats
Sudhir Patil1, T Prakash1, D Kotresha2, N Rama Rao3, Naitik Pandy1
1 Department of Pharmacology, Acharya and B.M. Reddy College of Pharmacy, Bangalore-560 090, India
2 Department of Biochemistry, Indian Institute of Science, Bangalore- 560 012, Karnataka, India
3 Department of Pharmaceutical Chemistry, Chalapathi Institute of Pharmaceutical Science, Guntur-522 034, Andhra Pradesh, India
Objective : To study the antihyperlipidemic effect of Cedrus deodara (C. deodara) against monosodium glutamate (MSG) induced obesity in neonatal rats.
Materials and Methods : The studies were carried out on newborn neonatal rats and were injected intraperitoneally with 2 mg/g of MSG on the 2 nd and 4 th postnatal days and 4 mg/g on 6 th , 8 th and 10 th postnatal days. Ethanolic extract (EE) and acetone extract (AE) of C. deodara was administered in a dose of 100 and 200 mg/kg, p.o./day at the age of 65 days. On day 60 of treatment, body weight, locomotor activity, body temperature, and various biochemical parameters like serum glucose, total cholesterol, triglyceride, and organs weights were recorded.
Results : There was a significant reduction in body weight, organs and increased body temperature, locomotor activity after treatment with extracts. C. deodara decreased serum glucose, total cholesterol and triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels and increased high density lipoprotein (HDL) significantly has compared to MSG-control rats.
Conclusion : C. deodara extracts exhibited antihyperlipidemic effect and it possesses anti-obesity properties in MSG induced obese rats.
Department of Pharmacology, Acharya and B.M. Reddy College of Pharmacy, Bangalore-560 090
Source of Support: None, Conflict of Interest: None
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